Biodistribution and internal radiation dosimetry of a novel probe for thymidine phosphorylase imaging, [123I]IIMU, in healthy volunteers
Sign Up to like & getrecommendations! Published in 2020 at "Annals of Nuclear Medicine"
DOI: 10.1007/s12149-020-01469-4
Abstract: We evaluated the radiation dosage, biodistribution, human safety, and tolerability of the injection of a single dose of [123I] 5-iodo-6-[(2-iminoimidazolidinyl)methyl]uracil (IIMU), a new radiotracer targeting thymidine phosphorylase (TP), in healthy volunteers. Potential participants were tested… read more here.
Keywords: thymidine phosphorylase; post injection; 123i iimu; healthy volunteers ... See more keywords
Multilevel virtual screening approach for discovery of thymidine phosphorylase inhibitors as potential anticancer agents
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Molecular Structure"
DOI: 10.1016/j.molstruc.2021.131648
Abstract: Abstract Thymidine phosphorylase (TP) is an enzyme which catalyses the conversion of thymidine to thymine and 2-deoxy-α- d -ribose-1-phosphate. The 2-deoxy-α- d -ribose-1-phosphate is then dephosphorylated to the 2-deoxy-α- d -ribose, which can promote angiogenesis,… read more here.
Keywords: thymidine phosphorylase; virtual screening; thymidine; multilevel virtual ... See more keywords
Evaluation of Thymidine Phosphorylase Inhibitors in Glioblastoma and Their Capacity for Temozolomide Potentiation.
Sign Up to like & getrecommendations! Published in 2021 at "ACS chemical neuroscience"
DOI: 10.1021/acschemneuro.1c00494
Abstract: A number of studies have shown high levels of thymidine phosphorylase (TP) expression in glioblastoma (GBM), with trace or undetectable TP levels in normal developed brain tissue. TP catalyzes the reversible phosphorolysis of thymidine to… read more here.
Keywords: thymidine phosphorylase; thymidine; inhibitors glioblastoma; evaluation thymidine ... See more keywords
Mesenchymal stem cells anchored with thymidine phosphorylase for doxifluridine-mediated cancer therapy
Sign Up to like & getrecommendations! Published in 2021 at "RSC Advances"
DOI: 10.1039/d0ra10263f
Abstract: Many tumors express thymidine phosphorylase (TYMP) with various levels, however due to tumor heterogeneity, the amount of TYMP is usually not enough to convert prodrug doxifluridine (5′-DFUR) to toxic drug 5-fluorouracil (5-FU). Since human mesenchymal… read more here.
Keywords: thymidine phosphorylase; doxifluridine; cancer; stem cells ... See more keywords
Quantitative Structure–Activity Relationship and Combinatorial Design of 1,3,4-Oxadiazole-Based Thymidine Phosphorylase Inhibitors as Potential Anti-Cancer Agents
Sign Up to like & getrecommendations! Published in 2018 at "Current Science"
DOI: 10.18520/cs/v114/i10/2063-2071
Abstract: The 3D quantitative structure–activity relationship model representing r = 0.8605, q = 0.8193 and pred_r = 0.6847 respectively, was generated for thymidine phosphorylase (TP) inhibitory activity of some 1,3,4-oxadiazole derivatives. Electronegative substituents at R and… read more here.
Keywords: thymidine phosphorylase; quantitative structure; activity relationship; structure activity ... See more keywords
Thymidine phosphorylase: the unforeseen driver in colorectal cancer treatment?
Sign Up to like & getrecommendations! Published in 2018 at "Future oncology"
DOI: 10.2217/fon-2017-0627
Abstract: 5-Fluorouracil- and leucovorin-based chemotherapy regimens are the backbone of colorectal cancer treatment. The addition of oxaliplatin, irinotecan and monoclonal antibodies to this backbone has largely improved clinical outcomes, but has also led to new questions,… read more here.
Keywords: thymidine phosphorylase; unforeseen driver; colorectal cancer; cancer treatment ... See more keywords
Targeting thymidine phosphorylase alleviates resistance to dendritic cell immunotherapy in colorectal cancer and promotes antitumor immunity
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Immunology"
DOI: 10.3389/fimmu.2022.988071
Abstract: T-cell exhaustion plays a pivotal role in the resistance of microsatellite-stable colorectal cancer (CRC) to immunotherapy. Identifying and targeting T-cell exhaustion-activating mechanisms is a promising strategy to augment the effects of immunotherapy. Here, we found… read more here.
Keywords: cell; dendritic cell; cell exhaustion; colorectal cancer ... See more keywords
Thymidine Phosphorylase Is Increased in COVID-19 Patients in an Acuity-Dependent Manner
Sign Up to like & getrecommendations! Published in 2021 at "Frontiers in Medicine"
DOI: 10.3389/fmed.2021.653773
Abstract: Coronavirus disease 2019 (COVID-19), caused by the severe acute respiratory syndrome coronavirus 2 (SARS-COV-2), is a human respiratory disease. Hitherto, there is no effective treatment has been established. Patients with cardiovascular or diabetes comorbidities are… read more here.
Keywords: thymidine phosphorylase; covid patients; medicine; phosphorylase increased ... See more keywords
Dihydropyrimidone Derivatives as Thymidine Phosphorylase Inhibitors: Inhibition Kinetics, Cytotoxicity, and Molecular Docking
Sign Up to like & getrecommendations! Published in 2023 at "Molecules"
DOI: 10.3390/molecules28083634
Abstract: Overexpression of the thymidine phosphorylase (TP) enzyme induces angiogenesis, which eventually leads to metastasis and tumor growth. The crucial role of TP in cancer development makes it an important target for anticancer drug discovery. Currently,… read more here.
Keywords: molecular docking; cytotoxicity; dihydropyrimidone; dihydropyrimidone derivatives ... See more keywords
Recent advances in thymidine phosphorylase inhibitors: syntheses and prospective medicinal applications
Sign Up to like & getrecommendations! Published in 2017 at "Turkish Journal of Chemistry"
DOI: 10.3906/kim-1602-79
Abstract: This review paper covers recent advances in the synthetic strategies for novel TPase inhibitors and their potential medicinal applications over the last few decades. A brief introduction covering the structural aspects of TPase inhibitors is… read more here.
Keywords: thymidine phosphorylase; advances thymidine; medicinal applications; inhibitors syntheses ... See more keywords