Sequence-Controlled Synthesis of Advanced Clickable Synthetic Oligonucleotides.
Sign Up to like & getrecommendations! Published in 2020 at "Macromolecular rapid communications"
DOI: 10.1002/marc.202000327
Abstract: Through thiol-ene photopolymerization of presynthesized oligomers, advanced clickable nucleic acids (CNA-2G) are synthesized with sequence-controlled repeating units. As examples, poly(thymine-adenine) (polyTA) CNA-2G and poly(thymine-thymine-cytosine) CNA-2G are synthesized by polymerizing thiol-ene heterofunctional dimers with pendant thymine-adenine… read more here.
Keywords: growth propagation; thiol ene; sequence controlled; advanced clickable ... See more keywords
Experimental and Theoretical Study of Strong Low-Terahertz Absorption of Thymine
Sign Up to like & getrecommendations! Published in 2017 at "Journal of Infrared, Millimeter, and Terahertz Waves"
DOI: 10.1007/s10762-017-0420-z
Abstract: The absorption coefficient of a nucleobase-thymine-in powder form was measured with terahertz spectroscopy in both frequency- and time-domain experiments. For frequencies below 3 THz, a strong signature was observed at 1.27 THz. Furthermore, molecular-dynamic simulations… read more here.
Keywords: absorption; theoretical study; experimental theoretical; study strong ... See more keywords
Au NP-Decorated g-C3N4-Based Photoelectochemical Biosensor for Sensitive Mercury Ions Analysis
Sign Up to like & getrecommendations! Published in 2022 at "ACS Omega"
DOI: 10.1021/acsomega.2c01335
Abstract: Herein, an efficient and feasible photoelectrochemical (PEC) biosensor based on gold nanoparticle-decorated graphitic-like carbon nitride (Au NPs@g-C3N4) with excellent photoelectric performance was designed for the highly sensitive detection of mercury ions (Hg2+) . The proposed… read more here.
Keywords: thymine; mercury ions; detection; biosensor ... See more keywords
Denaturation of dsDNA Induced by Specific Major Groove Binding of Cadmium Ion to Thymine
Sign Up to like & getrecommendations! Published in 2017 at "ACS Omega"
DOI: 10.1021/acsomega.7b01377
Abstract: The toxicity of cadmium causes varying degrees of risk to organisms. The underlying mechanism has been conventionally attributed to Cd2+-ion-induced oxidative stress. Here, we propose that the Cd2+ ion directly and stably binds with the… read more here.
Keywords: major groove; ion; cadmium; thymine ... See more keywords
Sequence-dependent thymine dimerization and lifetimes of the photoexcited state of oligonucleotides.
Sign Up to like & getrecommendations! Published in 2022 at "Chemical communications"
DOI: 10.1039/d2cc03902h
Abstract: DNA-sequence-dependent thymine-thymine (TT) dimerization was investigated from the perspective of the UV-induced charge transfer state. Steady-state and transient absorption measurements suggest that the relatively small oxidation potential and long-lived charge transfer state at the neighboring… read more here.
Keywords: thymine; state; sequence dependent; dependent thymine ... See more keywords
Abstract 6933: Ru(II)-thymine complex inhibits NF-κB activation, suppressing acute myeloid leukemia stem cells
Sign Up to like & getrecommendations! Published in 2025 at "Cancer Research"
DOI: 10.1158/1538-7445.am2025-6933
Abstract: Acute myeloid leukemia (AML) is a deadly blood cancer caused by leukemia blasts that fail to develop properly. AML has a significant relapse rate, which is attributed to a subset of cells known as leukemia… read more here.
Keywords: leukemia stem; acute myeloid; thymine; stem cells ... See more keywords
Differential Effects of Biomimetic Thymine Dimers and Corresponding Photo-Adducts in Primary Human Keratinocytes and Fibroblasts
Sign Up to like & getrecommendations! Published in 2024 at "Biomolecules"
DOI: 10.3390/biom14121484
Abstract: UVB radiation induces DNA damage generating several thymine photo-adducts (TDPs), which can lead to mutations and cellular transformation. The DNA repair pathways preserve genomic stability by recognizing and removing photodamage. These DNA repair side products… read more here.
Keywords: thymine dimers; thymine; biomimetic thymine; btds tdps ... See more keywords
Photochemistry of Thymine in Protic Polar Nanomeric Droplets Using Electrostatic Embeding TD-DFT/MM
Sign Up to like & getrecommendations! Published in 2021 at "Molecules"
DOI: 10.3390/molecules26196021
Abstract: Thymine photochemistry is important for understanding DNA photodamage. In the gas phase, thymine undergoes a fast non-radiative decay from S 2 to S 1 . In the S 1 state, it gets trapped for several… read more here.
Keywords: nanomeric droplets; protic polar; polar nanomeric; thymine protic ... See more keywords
Thymines opposite to bulky aristolactam-DNA adducts in duplex DNA are not targeted by human thymine-DNA glycosylase
Sign Up to like & getrecommendations! Published in 2025 at "PeerJ"
DOI: 10.7717/peerj.19577
Abstract: Background Consumption of aristolochic acids (AA) from the plant Aristolochia results in the formation of bulky aristolactam-dA (dA-AL) and aristolactam-dG (dG-AL) adducts in cellular DNA ultimately leading to the development of urothelial cancer. Intriguingly, the… read more here.
Keywords: adducts duplex; thymine dna; thymine; duplex dna ... See more keywords