Kinetic Analysis of the Effect of N-Terminal Acetylation on Thymine DNA Glycosylase.
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DOI: 10.1021/acs.biochem.1c00823
Abstract: Thymine DNA glycosylase (TDG) is tasked with initiating DNA base excision repair by recognizing and removing T, U, the chemotherapeutic 5-fluorouracil (5-FU), and many other oxidized and halogenated pyrimidine bases. TDG contains a long, unstructured… read more here.
Keywords: effect terminal; acetylation; dna; dna glycosylase ... See more keywords
Base-flipping dynamics from an intrahelical to an extrahelical state exerted by thymine DNA glycosylase during DNA repair process
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DOI: 10.1093/nar/gky386
Abstract: Abstract Thymine DNA glycosylase (TDG) is a DNA repair enzyme that excises a variety of mismatched or damaged nucleotides (nts), e.g. dU, dT, 5fC and 5caC. TDG is shown to play essential roles in maintaining… read more here.
Keywords: state; dna; base flipping; process ... See more keywords
Abstract 1940: Thymine DNA glycosylase (TDG) as a novel target for melanoma
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DOI: 10.1158/1538-7445.am2018-1940
Abstract: Melanoma is an aggressive neoplasm with increasing incidence that bears the infamous distinction of being a recalcitrant cancer, i.e. a cancer with poor prognosis, lacking progress in diagnosis and treatment. In addition to conventional therapy,… read more here.
Keywords: melanoma; tdg; dna glycosylase; thymine dna ... See more keywords
Excision of 5-carboxylcytosine by Thymine DNA Glycosylase
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DOI: 10.2210/pdb6u16/pdb
Abstract: 5-Methylcytosine (mC) is an epigenetic mark that is written by methyltransferases, erased through passive and active mechanisms, and impacts transcription, development, diseases including cancer, and aging. Active DNA demethylation involves TET-mediated stepwise oxidation of mC… read more here.
Keywords: carboxylcytosine; dna; thymine dna; excision ... See more keywords