Pyrimidine analogs as a new class of Gram-positive antibiotics, mainly targeting thymineless-death related proteins.
Sign Up to like & getrecommendations! Published in 2019 at "ACS infectious diseases"
DOI: 10.1021/acsinfecdis.9b00305
Abstract: Multidrug-resistant (MDR) bacteria are widespread throughout the world and pose an increasingly serious threat to human and animal health. Besides implementing strict measures to prevent improper antibiotic use, it remains essential that novel antibiotics must… read more here.
Keywords: gram positive; death; pyrimidine analogs; thymineless death ... See more keywords
Defects in the central metabolism prevent thymineless death in Escherichia coli, while still allowing significant protein synthesis.
Sign Up to like & getrecommendations! Published in 2024 at "Genetics"
DOI: 10.1093/genetics/iyae142
Abstract: Starvation of E. coli thyA auxotrophs for the required thymine or thymidine leads to cessation of DNA synthesis and, unexpectedly, to thymineless death (TLD). Previously, TLD-alleviating defects were identified by the candidate gene approach, for… read more here.
Keywords: tld; thymineless death; synthesis; central metabolism ... See more keywords