Knockout of SLy1 decreases double‐negative thymocyte proliferation and protects mice from p53‐induced tumor formation
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DOI: 10.1002/eji.202250017
Abstract: The lymphocyte‐specific adapter protein SLy1 has previously been identified as indispensable for thymocyte development and T‐cell proliferation and, recently, as a cause of X‐linked combined immunodeficiency in humans that recapitulates many of the abnormalities reported… read more here.
Keywords: proliferation; thymocyte; tumor formation; p53 ... See more keywords
Integrative Single-Cell Transcriptomic Analysis of Human Fetal Thymocyte Development
Sign Up to like & getrecommendations! Published in 2021 at "Frontiers in Genetics"
DOI: 10.3389/fgene.2021.679616
Abstract: Intrathymic differentiation of T lymphocytes begins as early as intrauterine stage, yet the T cell lineage decisions of human fetal thymocytes at different gestational ages are not currently understood. Here, we performed integrative single-cell analyses… read more here.
Keywords: integrative single; thymocyte; human fetal; thymocyte development ... See more keywords