Prospective Open-Label Phase II Trial of Individualized Anti-Thymocyte Globulin for Improved T-Cell Reconstitution after Pediatric Allogeneic Hematopoietic Cell Transplantation: The Parachute-Study
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DOI: 10.1016/j.bbmt.2019.12.577
Abstract: Introduction Rabbit anti-thymocyte globulin (ATG) is used in allogeneic hematopoietic cell transplantation (HCT) to prevent graft-versus-host-disease (GvHD) and graft failure (GF). Its main and unpredictable toxicity includes poor immune reconstitution associated with increased relapse, viral… read more here.
Keywords: anti thymocyte; thymocyte globulin; cell reconstitution; reconstitution ... See more keywords
Impact of anti-thymocyte globulin on results of allogeneic peripheral blood stem cell transplantation for patients with Philadelphia-positive acute lymphoblastic leukaemia: An analysis by the Acute Leukemia Working Party of the EBMT.
Sign Up to like & getrecommendations! Published in 2019 at "European journal of cancer"
DOI: 10.1016/j.ejca.2018.11.003
Abstract: BACKGROUND Anti-thymocyte globulin (ATG) is widely used to prevent graft-versus-host disease (GVHD) after allogeneic peripheral blood stem cell transplantation (alloPBSCT). The goal of this study was to retrospectively assess the effect of ATG on outcomes… read more here.
Keywords: anti thymocyte; risk; acute; thymocyte globulin ... See more keywords
Impaired thymopoiesis predicts for a high risk of severe infections after reduced intensity conditioning without anti-thymocyte globulin in double umbilical cord blood transplantation
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DOI: 10.1038/s41409-018-0103-y
Abstract: Umbilical cord blood stem cell transplantation (UCBT) is associated with retarded hematopoietic recovery and immune reconstitution and a high infection-related morbidity and mortality, especially after conditioning including anti-thymocyte globulin (ATG). However, data on immune recovery,… read more here.
Keywords: anti thymocyte; cord blood; thymocyte globulin; umbilical cord ... See more keywords
Clinical Experience of 6 Years with Rabbit Anti-Thymocyte Globulin as Induction Therapy in Renal Transplant Receptors
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DOI: 10.1097/01.tp.0000543483.81961.c2
Abstract: The rabbit-derived anti-thymocyte globulin (rATG/ThymoglobulineÒ) is currently the most commonly used drug in induction therapy regimens in kidney transplantation worldwide. Objective Success rate in the survival of the renal graft and adverse effects at one… read more here.
Keywords: anti thymocyte; thymocyte globulin; induction therapy; transplant ... See more keywords
COMPARISON OF ALEMTUZUMAB AND ANTI-THYMOCYTE GLOBULIN TREATMENT FOR ACUTE KIDNEY ALLOGRAFT REJECTION
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DOI: 10.1097/01.tp.0000700412.64126.c3
Abstract: Introduction: Rabbit anti-thymocyte globulin (rATG) is currently the treatment of choice for glucocorticoid-resistant, recurrent or severe acute allograft rejection (AR). However, rATG is associated with severe infusion-related side effects. Alemtuzumab is incidentally given to kidney… read more here.
Keywords: anti thymocyte; thymocyte globulin; treatment; rejection ... See more keywords
The effect of anti‐thymocyte globulin and everolimus on the kinetics of cytomegalovirus viral load in seropositive kidney transplant recipients without prophylaxis
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DOI: 10.1111/tid.12919
Abstract: The use of mTOR inhibitors is associated with lower incidence of CMV infections but its effect on viral load has not been investigated. read more here.
Keywords: anti thymocyte; thymocyte globulin; effect anti; effect ... See more keywords
Reduced Risk of Chronic Graft-Versus-Host Disease (cGVHD) by Rabbit Anti-Thymocyte Globulin (ATG) in Patients Undergoing Matched Sibling Donor Transplantation in Hematological Malignancies
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DOI: 10.12659/aot.937356
Abstract: Background With the addition of anti-thymocyte globulin (ATG) to GVHD prophylaxis in patients undergoing transplantation of peripheral blood stem cells (PBSCT), the incidence of cGVHD decreases. However, the optimal dose and timing of ATG remain… read more here.
Keywords: thymocyte globulin; atg; globulin atg; anti thymocyte ... See more keywords
Systematic review and meta-analysis of anti-thymocyte globulin dosage as a component of graft-versus-host disease prophylaxis.
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DOI: 10.1371/journal.pone.0284476
Abstract: Rabbit anti-thymocyte globulin (ATG) has been used in allogeneic hematopoietic stem cell transplantation (Allo-HSCT) for graft-versus-host disease (GvHD) prophylaxis. Since the best dose has not been defined yet, this study aimed to determine the efficacy… read more here.
Keywords: thymocyte globulin; host disease; versus host; anti thymocyte ... See more keywords
Allogeneic peripheral blood stem cell transplantation with anti-thymocyte globulin versus allogeneic bone marrow transplantation without anti-thymocyte globulin
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DOI: 10.3324/haematol.2019.227603
Abstract: We compared severe graft-versus-host-disease (GvHD) free and relapse-free survival and other transplantation outcomes of acute myeloid leukemia (AML) patients given bone marrow (BM) without anti-thymocyte globulin (ATG) versus peripheral blood stem cells (PBSC) with ATG… read more here.
Keywords: anti thymocyte; thymocyte globulin; transplantation; survival ... See more keywords
Siplizumab, an Anti-CD2 Monoclonal Antibody, Induces a Unique Set of Immune Modulatory Effects Compared to Alemtuzumab and Rabbit Anti-Thymocyte Globulin In Vitro
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DOI: 10.3389/fimmu.2020.592553
Abstract: Antibodies are commonly used in organ transplant induction therapy and to treat autoimmune disorders. The effects of some biologics on the human immune system remain incompletely characterized and a deeper understanding of their mechanisms of… read more here.
Keywords: anti thymocyte; thymocyte globulin; antibody; alemtuzumab rabbit ... See more keywords
Therapeutic Drug Monitoring of Anti-Thymocyte Globulin in Allogeneic Stem Cell Transplantation: Proof of Concept
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DOI: 10.3389/fphar.2022.828094
Abstract: Anti-thymocyte globulin (ATG), a polyclonal antibody, is used in allogeneic hematopoietic cell transplantation (HCT) to prevent graft-vs.-host-disease (GvHD) and graft failure (GF). Overexposure to ATG leads to poor early T-cell recovery, which is associated with… read more here.
Keywords: thymocyte globulin; cell; therapeutic drug; cell transplantation ... See more keywords