Exploring the possible mitoprotective and neuroprotective potency of thymoquinone, betanin, and vitamin D against cytarabine‐induced mitochondrial impairment and neurotoxicity in rats' brain
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Biochemical and Molecular Toxicology"
DOI: 10.1002/jbt.23256
Abstract: It has been suggested that cytarabine (Ara‐C) induces toxicity via mitochondrial dysfunction and oxidative stress. Therefore, we hypothesized that mitochondrial protective agents and antioxidants can reduce cytarabine‐induced neurotoxicity. For this purpose, 48 male Wistar rats… read more here.
Keywords: brain; group; cytarabine; thymoquinone ... See more keywords
Investigating binding mechanism of thymoquinone to human transferrin, targeting Alzheimer's disease therapy
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Cellular Biochemistry"
DOI: 10.1002/jcb.30299
Abstract: Iron deposition in the central nervous system (CNS) is one of the causes of neurodegenerative diseases. Human transferrin (hTf) acts as an iron carrier present in the blood plasma, preventing it from contributing to redox… read more here.
Keywords: thymoquinone; alzheimer disease; human transferrin; htf ... See more keywords
Covid‐19 and thymoquinone: Connecting the dots
Sign Up to like & getrecommendations! Published in 2020 at "Phytotherapy Research"
DOI: 10.1002/ptr.6793
Abstract: At present, the medical approaches to cope with Covid-19 infection caused by the respiratory syndrome coronavirus 2 (SARS-CoV-2) are mainly supportive. In the absence of specific anti-viral therapies or vaccines, the medical care is complemented… read more here.
Keywords: sepsis; thymoquinone; alkharfy; inflammatory cytokines ... See more keywords
Thymoquinone improves folliculogenesis, sexual hormones, gene expression of apoptotic markers and antioxidant enzymes in polycystic ovary syndrome rat model
Sign Up to like & getrecommendations! Published in 2022 at "Veterinary Medicine and Science"
DOI: 10.1002/vms3.958
Abstract: Abstract Background Nowadays, polycystic ovary syndrome (PCOS) is a prevalent cause of infertility affecting women of reproductive age around the world. Thymoquinone is a natural antioxidant, derived from Nigella sativa. Objectives The current study aimed… read more here.
Keywords: thymoquinone; pcos; gene expression; polycystic ovary ... See more keywords
Endothelium‐dependent contractions depending on biased sGC activation: The Janus face of thymoquinone: O36
Sign Up to like & getrecommendations! Published in 2017 at "Biochemical Pharmacology"
DOI: 10.1016/j.bcp.2017.06.101
Abstract: Objective Thymoquinone, a major component of black seed oil, has beneficial (vasodilator, antioxidative and anti-inflammatory) effects in the cardiovascular system. Previous experiments in isolated arteries indicate that thymoquinone causes augmentations of contraction. The present study… read more here.
Keywords: endothelium; endothelium dependent; thymoquinone; biased sgc ... See more keywords
Improvement of antihyperglycemic activity of nano-thymoquinone in rat model of type-2 diabetes.
Sign Up to like & getrecommendations! Published in 2018 at "Chemico-biological interactions"
DOI: 10.1016/j.cbi.2018.02.006
Abstract: Thymoquinone is a bioactive constituent of Nigella sativa seeds. It has been reported to possess antihyperglycemic effect in rats. However, the effect of nanoformulation (NF) of thymoquinone has not been reported in literature. So, the… read more here.
Keywords: thymoquinone; effect; thymoquinone metformin; antihyperglycemic effect ... See more keywords
Thymoquinone loaded dermal lipid nano particles: Box Behnken design optimization to preclinical psoriasis assessment
Sign Up to like & getrecommendations! Published in 2019 at "Journal of Drug Delivery Science and Technology"
DOI: 10.1016/j.jddst.2019.05.041
Abstract: Abstract The present study was to formulate and optimize Thymoquinone (TQ) lipid nanoparticles (NPs) formulations for the treatment of psoriasis. The formulation optimization was performed using the independent variables [(gelucire (A), capmul (B), sonication time(C)]… read more here.
Keywords: optimization; psoriasis; lipid nano; study ... See more keywords
Thymoquinone loaded chitosan - Solid lipid nanoparticles: Formulation optimization to oral bioavailability study
Sign Up to like & getrecommendations! Published in 2021 at "Journal of Drug Delivery Science and Technology"
DOI: 10.1016/j.jddst.2021.102565
Abstract: Abstract High lipophilicity, low bioavailability, and hostile gastrointestinal (GI) environment is the major concern in oral administration of thymoquinone (TQ). Herein, we developed chitosan (CS) modified solid lipid nanoparticles (SLNs) to improve oral bioavailability. SLNs… read more here.
Keywords: bioavailability; lipid nanoparticles; thymoquinone; oral bioavailability ... See more keywords
Synthesis of Thymoquinone-Artemisinin Hybrids: New Potent Antileukemia, Antiviral, and Antimalarial Agents.
Sign Up to like & getrecommendations! Published in 2018 at "ACS medicinal chemistry letters"
DOI: 10.1021/acsmedchemlett.7b00412
Abstract: A series of hybrid compounds based on the natural products artemisinin and thymoquinone was synthesized and investigated for their biological activity against the malaria parasite Plasmodium falciparum 3D7 strain, human cytomegalovirus (HCMV), and two leukemia… read more here.
Keywords: artemisinin hybrids; thymoquinone; thymoquinone artemisinin; hybrids new ... See more keywords
Thymoquinone Induces Nrf2 Mediated Adaptive Homeostasis: Implication for Mercuric Chloride-Induced Nephrotoxicity
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DOI: 10.1021/acsomega.2c00028
Abstract: Background: the primary function of the kidney is to eliminate metabolic waste products and xenobiotics from the circulation. During this process, the kidney may become vulnerable to toxicity. Objective: it was aimed to investigate the… read more here.
Keywords: induced nephrotoxicity; hgcl2; expression; thymoquinone ... See more keywords
Thymoquinone Induced Leishmanicidal Effect via Programmed Cell Death in Leishmania donovani
Sign Up to like & getrecommendations! Published in 2022 at "ACS Omega"
DOI: 10.1021/acsomega.2c00467
Abstract: Visceral leishmaniasis (VL) or kala-azar is a vector-borne dreaded protozoal infection that is caused by the parasite Leishmania donovani. With increases in the dramatic infection rates, present drug toxicity, resistance, and the absence of an… read more here.
Keywords: thymoquinone; cell death; leishmanicidal effect;