Metal coordination of thymosin β4: Chemistry and possible implications
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DOI: 10.1016/j.ccr.2019.06.008
Abstract: Abstract Thymosin β4 (Tβ4) was first isolated in the ‘60ies from calf thymus and was initially perceived as a thymic hormone with immunological effects on lymphocytes. It was then identified as a G-actin binding protein,… read more here.
Keywords: thymosin; metal coordination; coordination thymosin; thymosin chemistry ... See more keywords
Thymosin β4 and the vasculature: multiple roles in development, repair and protection against disease
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DOI: 10.1080/14712598.2018.1459558
Abstract: ABSTRACT Introduction: Formation of the vasculature is a complex process, defects in which can lead to embryonic lethality or disease in later life. Understanding mechanisms of vasculogenesis may facilitate the treatment of developmental defects and… read more here.
Keywords: vasculature; disease; protection disease; thymosin ... See more keywords
The effect of thymosin α1 for prevention of infection in patients with severe acute pancreatitis
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DOI: 10.1080/14712598.2018.1481207
Abstract: ABSTRACT Introduction: Severe acute pancreatitis (SAP) is an acute inflammatory disease with prolonged clinical course, which is complicated by the presence of persistent organ failure and severe infection. Infection mainly occurs in the late phase… read more here.
Keywords: sap related; severe acute; infection; related infection ... See more keywords
Cellular proteostasis: a new twist in the action of thymosin α1
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DOI: 10.1080/14712598.2018.1484103
Abstract: ABSTRACT Introduction: Thymosin alpha 1 (Tα1) is a naturally occurring polypeptide of 28 amino acids, whose mechanism of action is thought to be related to its ability to signal through innate immune receptors. Tα1 (ZADAXIN®)… read more here.
Keywords: new twist; cellular proteostasis; proteostasis new; thymosin ... See more keywords
Thymosin β4: potential to treat epidermolysis bullosa and other severe dermal injuries
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DOI: 10.1684/ejd.2019.3642
Abstract: Thymosin β4 is a naturally-occurring regenerative protein present in almost all cells and body fluids, including wound fluid. In multiple preclinical injury models, it promotes dermal repair and tissue regeneration. Thymosin β4 acts by increasing… read more here.
Keywords: thymosin; epidermolysis bullosa; epidermolysis; potential treat ... See more keywords