Janus kinase inhibitor ruxolitinib blocks thymic regeneration after acute thymus injury.
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DOI: 10.1016/j.bcp.2019.113712
Abstract: Thymic epithelial cells (TECs) are crucial for the production of T-cells. Cancer therapies including cytotoxic drugs and ionizing radiations damage TECs resulting in abnormal T-cell production and function. Fortunately, TECs can regenerate after injury. The… read more here.
Keywords: ruxolitinib; thymus injury; regeneration; injury ... See more keywords