Impact of High-Throughput Model Parameterization and Data Uncertainty on Thyroid-Based Toxicological Estimates for Pesticide Chemicals.
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DOI: 10.1021/acs.est.1c07143
Abstract: Chemical-induced alteration of maternal thyroid hormone levels may increase the risk of adverse neurodevelopmental outcomes in offspring. US federal risk assessments rely almost exclusively on apical endpoints in animal models for deriving points of departure… read more here.
Keywords: parameterization; thyroid based; pesticide chemicals; model parameterization ... See more keywords