Using Ion Torrent sequencing to study genetic mutation profiles of fatal thyroid cancers.
Sign Up to like & getrecommendations! Published in 2018 at "Journal of the Formosan Medical Association = Taiwan yi zhi"
DOI: 10.1016/j.jfma.2017.05.007
Abstract: BACKGROUND/PURPOSE Surgery followed by radioiodine is a mainstay of treatment for thyroid cancers of follicular origins. However, about 5% of the thyroid cancers are non-operable and/or radioiodine-refractory diseases, which are either locally advanced or metastatic… read more here.
Keywords: mutation; fatal thyroid; thyroid cancers; ion torrent ... See more keywords
Abstract CT011: Efficacy and safety of selpercatinib in RET fusion-positive cancers other than lung or thyroid cancers
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DOI: 10.1158/1538-7445.am2021-ct011
Abstract: Introduction: Selpercatinib, a first-in-class highly selective and potent RET kinase inhibitor, is approved in multiple countries for the treatment of RET fusion-positive lung or thyroid cancers. RET fusions are also implicated in the pathogenesis of… read more here.
Keywords: fusion positive; thyroid cancers; non; ret fusion ... See more keywords
Cardiac Metastasis from Medullary Thyroid Cancers with Long-Term Survival under Vandetanib
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DOI: 10.1159/000517716
Abstract: Background: Cardiac metastases from thyroid cancers are uncommon with a poor prognosis. There is a lack of long-term follow-up studies. Cases: We report 2 cases of cardiac metastasis from medullary thyroid cancer (MTC). Both patients… read more here.
Keywords: metastasis; long term; cardiac metastasis; thyroid cancers ... See more keywords
Mutational analysis of radiation-induced subsequent thyroid cancers in pediatric patients.
Sign Up to like & getrecommendations! Published in 2020 at "Journal of Clinical Oncology"
DOI: 10.1200/jco.2020.38.15_suppl.e22531
Abstract: e22531Background: The genetic landscape of radiation induced pediatric thyroid cancers is unclear. Radiation (RT) induced thyroid cancers frequently demonstrate tumorigenesis driven by fusion oncog... read more here.
Keywords: radiation induced; thyroid cancers; mutational analysis; analysis radiation ... See more keywords
Immune responses in the thyroid cancer microenvironment: making immunotherapy a possible mission.
Sign Up to like & getrecommendations! Published in 2017 at "Endocrine-related cancer"
DOI: 10.1530/erc-17-0316
Abstract: The incidence of thyroid cancers has been steadily increasing worldwide over the past few decades. Although five-year survival rates for differentiated thyroid cancers are upwards of 90%, clinical outcomes for patients with undifferentiated, recurrent and/or… read more here.
Keywords: immune; thyroid cancer; cancer microenvironment; thyroid cancers ... See more keywords
Redifferentiation of radioiodine-refractory thyroid cancers.
Sign Up to like & getrecommendations! Published in 2020 at "Endocrine-related cancer"
DOI: 10.1530/erc-19-0491
Abstract: The management of radioiodine refractory thyroid cancers (RAIR TC) is challenging for the clinician. Tyrosine kinase inhibitors classically prescribed in this setting can fail due to primary or acquired resistance or the necessity of drug… read more here.
Keywords: refractory thyroid; radioiodine refractory; thyroid cancers;
Molecular mechanisms of resistance to kinase inhibitors in thyroid cancers.
Sign Up to like & getrecommendations! Published in 2022 at "Endocrine-related cancer"
DOI: 10.1530/erc-22-0129
Abstract: Protein kinases play critical roles in cell survival, proliferation and motility. Their dysregulation is therefore a common feature in the pathogenesis of a number of solid tumors, including thyroid cancers. Inhibiting activated protein kinases has… read more here.
Keywords: thyroid cancers; molecular mechanisms; kinase; mechanisms resistance ... See more keywords
Deiodinases in thyroid tumorigenesis
Sign Up to like & getrecommendations! Published in 2023 at "Endocrine-Related Cancer"
DOI: 10.1530/erc-23-0015
Abstract: The three deiodinase selenoenzymes are key regulators of intracellular thyroid hormone (TH) levels. The two TH-activating deiodinases (type 1 deiodinase and type 2 deiodinase (D2)) are normally expressed in follicular thyroid cells and contribute to… read more here.
Keywords: thyroid cancers; type deiodinase; thyroid tumorigenesis; deiodinase ... See more keywords
Signaling Dynamics of TSHR-Specific CAR-T Cells Revealed by FRET-Based Biosensors
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Cell and Developmental Biology"
DOI: 10.3389/fcell.2022.845319
Abstract: Although most patients with thyroid cancers have good prognosis and long-term survival, some patients are refractory to traditional therapeutic approaches and face a high risk of mortality. CAR-T therapy provides an attractive strategy to treat… read more here.
Keywords: car; car cells; fret based; thyroid cancers ... See more keywords
Targeting GLI1 Transcription Factor for Restoring Iodine Avidity with Redifferentiation in Radioactive-Iodine Refractory Thyroid Cancers
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DOI: 10.3390/cancers14071782
Abstract: Simple Summary Thyroid cancers have an excellent prognosis by standard therapy of surgery followed by radioactive-iodine therapy. However, metastatic thyroid cancers do not response to radioactive-iodine therapy by losing iodine avidity. Therefore, reversing iodine avidity… read more here.
Keywords: thyroid cancers; radioactive iodine; thyroid; therapy ... See more keywords
Limited Clinical and Diagnostic Utility of Circulating Tumor DNA Detection in Patients with Early-Stage Well-Differentiated Thyroid Cancer: Comparison with Benign Thyroid Nodules and Healthy Individuals
Sign Up to like & getrecommendations! Published in 2021 at "Healthcare"
DOI: 10.3390/healthcare9040386
Abstract: Limited data are available on the diagnostic utility of circulating tumor DNA (ctDNA) in early-stage thyroid cancers for BRAF, KRAS, NRAS, and TERT promoter mutations, which are known detectable markers for thyroid cancers. Here, we… read more here.
Keywords: utility; healthy individuals; thyroid cancers; early stage ... See more keywords