In silico prediction models for thyroid peroxidase inhibitors and their application to synthetic flavors
Sign Up to like & getrecommendations! Published in 2022 at "Food Science and Biotechnology"
DOI: 10.1007/s10068-022-01041-y
Abstract: Systematic toxicity tests are often waived for the synthetic flavors as they are added in a very small amount in foods. However, their safety for some endpoints such as endocrine disruption should be concerned as… read more here.
Keywords: synthetic flavors; models thyroid; prediction models; silico prediction ... See more keywords
Establishing thresholds and effects of gender, age, and season for thyroglobulin and thyroid peroxidase antibodies by mining real-world big data.
Sign Up to like & getrecommendations! Published in 2019 at "Clinical biochemistry"
DOI: 10.1016/j.clinbiochem.2019.08.011
Abstract: BACKGROUND Thyroglobulin antibody (TG-Ab) and thyroid peroxidase antibody (TPO-Ab) are cornerstone biomarkers for autoimmune thyroid diseases, and establishment of appropriate thresholds is crucial for physicians to appropriately interpret test results. Therefore, we established the thresholds… read more here.
Keywords: biochemistry; big data; age; gender age ... See more keywords
Thyroid peroxidase identified in human granulosa cells: another piece to the thyroid-ovary puzzle?
Sign Up to like & getrecommendations! Published in 2017 at "Gynecological Endocrinology"
DOI: 10.1080/09513590.2017.1296424
Abstract: Abstract Thyroid hormones seemingly influence the maturation of the human oocyte. Thyroid hormone receptors have been isolated in granulosa mural and cumulus cells and the mature oocyte of the human ovarian follicle. Thyroid hormones are… read more here.
Keywords: granulosa cells; granulosa; thyroid hormones; thyroid peroxidase ... See more keywords
Identification of metastatic papillary thyroid carcinoma in FNA specimens using thyroid peroxidase immunohistochemistry
Sign Up to like & getrecommendations! Published in 2018 at "Cytopathology"
DOI: 10.1111/cyt.12531
Abstract: We evaluated immunohistochemical staining for thyroid peroxidase (TPO), a glycoprotein found in the apical plasma membrane of thyroid follicular cells, as a marker for metastatic PTC in FNA samples and compared results with thyroglobulin (Tg)… read more here.
Keywords: fna; peroxidase; metastatic papillary; thyroid peroxidase ... See more keywords
Relationship between Gene Polymorphisms and Urine Iodine Levels on Susceptibility to Thyroid Peroxidase Antibody Positivity in the Chinese Population
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DOI: 10.1159/000506701
Abstract: Background/Aims: Hashimoto thyroiditis, characterized by positive thyroid peroxidase antibodies (TPOAbs), is caused by the interaction of genetic and environment factors. The aim of this study was to clarify the interaction of gene polymorphisms and iodine… read more here.
Keywords: risk; thyroid peroxidase; positivity; tpoab ... See more keywords
Development and validation of an ELISA for a biomarker of thyroid dysfunction, thyroid peroxidase autoantibodies (TPO-Ab), in dried blood spots
Sign Up to like & getrecommendations! Published in 2020 at "Journal of Physiological Anthropology"
DOI: 10.1186/s40101-020-00228-8
Abstract: Background The prevalence of allergic and autoimmune conditions has been steadily increasing in wealthy nations over the past century. One hypothesis put forward to explain this is the Old Friends Hypothesis, which posits that increased… read more here.
Keywords: validation; dbs samples; dried blood; dbs ... See more keywords
Thyroid peroxidase (TPO) expressed in thyroid and breast tissues shows similar antigenic properties
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DOI: 10.1371/journal.pone.0179066
Abstract: Background Thyroid peroxidase (TPO) is essential for physiological function of the thyroid gland. The high prevalence of thyroid peroxidase antibodies (TPOAbs) in patients with breast cancer and their protective role had previously been demonstrated, indicating… read more here.
Keywords: thyroid peroxidase; breast; breast cancer; tpo ... See more keywords
The polymorphisms in the thyroid peroxidase gene were associated with the development of autoimmune thyroid disease and the serum levels of anti-thyroid peroxidase antibody.
Sign Up to like & getrecommendations! Published in 2017 at "Endocrine journal"
DOI: 10.1507/endocrj.ej17-0191
Abstract: Graves' disease (GD) and Hashimoto's disease (HD) are well known autoimmune thyroid diseases (AITDs), and the severity and intractability of AITDs varies among patients. Thyroid peroxidase (TPO) is a thyroid-specific antigen. The levels of anti-thyroid… read more here.
Keywords: peroxidase; aitd; tpo; serum levels ... See more keywords
Cryo-electron microscopy structures of human thyroid peroxidase (TPO) in complex with TPO antibodies
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Molecular Endocrinology"
DOI: 10.1530/jme-22-0149
Abstract: Determination of the structure of the extracellular domain of human thyroid peroxidase (hTPO) by cryo-electron microscopy (cryo-EM) is described. TPO, purified to homogeneity was complexed with the hTPO monoclonal autoantibody 2G4 Fab and also with… read more here.
Keywords: human thyroid; tpo; microscopy; domain ... See more keywords
Some Dietary Phenolic Compounds Can Activate Thyroid Peroxidase and Inhibit Lipoxygenase-Preliminary Study in the Model Systems
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DOI: 10.3390/ijms22105108
Abstract: The presented research concerns the triple activity of trans-cinnamic (tCA), ferulic (FA) and syringic acids (SA). They act as thyroid peroxidase (TPO) activators, lipoxygenase (LOX) inhibitors and show antiradical activity. All compounds showed a dose-dependent… read more here.
Keywords: peroxidase; dietary phenolic; phenolic compounds; tca ... See more keywords
Utilization of Anti-Thyroid Peroxidase Antibody in Local Clinics and Hospitals and Intraindividual Changes in Korean Patients.
Sign Up to like & getrecommendations! Published in 2021 at "Clinical laboratory"
DOI: 10.7754/clin.lab.2021.201227
Abstract: BACKGROUND Limited data are available for test utilization and intraindividual changes in anti-thyroid peroxidase antibodies (anti-TPO Ab) in Korean patients. METHODS Using a laboratory information system, we retrospectively investigated longitudinally measured anti-TPO Ab along with… read more here.
Keywords: local clinics; anti thyroid; korean patients; thyroid peroxidase ... See more keywords