Sensitive Sequencing Analysis Suggests Thyrotropin Receptor and Guanine Nucleotide-Binding Protein G Subunit Alpha as Sole Driver Mutations in Hot Thyroid Nodules
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DOI: 10.1089/thy.2019.0648
Abstract: Background: Constitutively activating mutations in the thyrotropin receptor (TSHR) and the guanine nucleotide-binding protein G subunit alpha (GNAS) are the primary cause of hot thyroid nodules (HT... read more here.
Keywords: protein subunit; binding protein; thyrotropin receptor; nucleotide binding ... See more keywords
Consistency Between Thyrotropin Receptor Antibody (TRAb) and Thyroid-Stimulating Antibody (TSAb) Levels in Patients with Graves Disease.
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DOI: 10.1093/labmed/lmac008
Abstract: OBJECTIVE To investigate the consistency between thyrotropin receptor antibody (TRAb) and thyroid-stimulating antibody (TSAb) levels in patients with Graves disease (GD). METHODS We performed a cross-sectional observational study to recruit eligible patients with GD who… read more here.
Keywords: thyrotropin receptor; tsab levels; consistency thyrotropin; tsab ... See more keywords
Total Thyroidectomy for Thyroid Cancer Followed by Thyroid Storm due to Thyrotropin Receptor Antibody Stimulation of Metastatic Thyroid Tissue
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DOI: 10.1159/000479061
Abstract: Background: Graves disease (GD) is an autoimmune condition characterized by the presence of antibodies against the thyrotropin receptor (TRAB), which stimulate the thyroid gland to produce excess thyroid hormone. Theoretically, TRAB could stimulate highly differentiated… read more here.
Keywords: tissue; thyroid cancer; thyroid; thyrotropin receptor ... See more keywords
Neonates Born to Mothers with Graves' Disease: 15 Year Experience of a Pediatric Endocrinology Department.
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DOI: 10.20344/amp.12279
Abstract: INTRODUCTION Graves disease is characterized by the existence of autoantibodies directed to the thyrotropin receptor, which can have a stimulatory/inhibitory action, in women with the condition, their fetus or neonate. Our aim was to review the… read more here.
Keywords: directed thyrotropin; endocrinology; born mothers; graves disease ... See more keywords