Cardiac thyrotropin-releasing hormone (TRH) inhibition improves ventricular function and reduces hypertrophy and fibrosis after myocardial infarction in rats.
Sign Up to like & getrecommendations! Published in 2021 at "Journal of cardiac failure"
DOI: 10.1016/j.cardfail.2021.04.003
Abstract: BACKGROUND Cardiac thyrotropin-releasing hormone (TRH) is a tripeptide with still unknown functions. We demonstrated that the left ventricle (LV) TRH system is hyperactivated in spontaneously hypertensive rats and its inhibition prevented cardiac hypertrophy and fibrosis.… read more here.
Keywords: function; inhibition; thyrotropin releasing; trh ... See more keywords
Repeatability of a thyrotropin-releasing hormone stimulation test for diagnosis of pituitary pars intermedia dysfunction in mature horses.
Sign Up to like & getrecommendations! Published in 2021 at "Journal of veterinary internal medicine"
DOI: 10.1111/jvim.16281
Abstract: BACKGROUND Pituitary pars intermedia dysfunction (PPID) is a common endocrinopathy of horses diagnosed with a thyrotropin-releasing hormone (TRH) stimulation test. HYPOTHESIS/OBJECTIVES Describe the repeatability of TRH stimulation in horses with and without PPID in winter… read more here.
Keywords: releasing hormone; stimulation; repeatability; thyrotropin releasing ... See more keywords
Thyrotropin-releasing hormone analog as a stable upper airway-preferring respiratory stimulant with arousal properties
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Applied Physiology"
DOI: 10.1152/japplphysiol.00414.2022
Abstract: Taltirelin is a stable, brain-penetrating thyrotropin-releasing hormone (TRH) analog with minimal endocrine activity and potential respiratory stimulant properties. Taltirelin's receptor target shows high differential expression at the hypoglossal motor nucleus, and local taltirelin microperfusion into… read more here.
Keywords: taltirelin; arousal; thyrotropin releasing; respiratory ... See more keywords
Pancreatic Thyrotropin Releasing Hormone and Mechanism of Insulin Secretion
Sign Up to like & getrecommendations! Published in 2018 at "Cellular Physiology and Biochemistry"
DOI: 10.1159/000494013
Abstract: Thyrotropin releasing hormone (TRH; pGlu-His-ProNH2) is expressed also in pancreatic β cells where it is colocalized in secretory granules with insulin. High perinatal changes of the TRH gene expression and TRH concentrations in rat pancreatic… read more here.
Keywords: insulin; releasing hormone; secretion; insulin secretion ... See more keywords
SUN-465 Thyrotropin-Releasing Hormone-Degrading Ectoenzyme Controls Thyrotropin Secretion and Body Weight in Male Rodents
Sign Up to like & getrecommendations! Published in 2019 at "Journal of the Endocrine Society"
DOI: 10.1210/js.2019-sun-465
Abstract: Abstract Thyrotropin-releasing hormone (TRH) is expressed in the brain, and a few peripheral tissues. Apart from controlling TSH secretion from the pituitary, it has an anorexic effect. TRH is a short-lived intercellular signaling molecule, hydrolyzed… read more here.
Keywords: trh; mice; activity; trh activity ... See more keywords
Tanycytes and the Control of Thyrotropin-Releasing Hormone Flux Into Portal Capillaries
Sign Up to like & getrecommendations! Published in 2019 at "Frontiers in Endocrinology"
DOI: 10.3389/fendo.2019.00401
Abstract: Central and peripheral mechanisms that modulate energy intake, partition and expenditure determine energy homeostasis. Thyroid hormones (TH) regulate energy expenditure through the control of basal metabolic rate and thermogenesis; they also modulate food intake. TH… read more here.
Keywords: releasing hormone; energy; hpt axis; thyrotropin releasing ... See more keywords
The Thyrotropin-Releasing Hormone-Degrading Ectoenzyme, a Therapeutic Target?
Sign Up to like & getrecommendations! Published in 2020 at "Frontiers in Pharmacology"
DOI: 10.3389/fphar.2020.00640
Abstract: Thyrotropin releasing hormone (TRH: Glp-His-Pro-NH2) is a peptide mainly produced by brain neurons. In mammals, hypophysiotropic TRH neurons of the paraventricular nucleus of the hypothalamus integrate metabolic information and drive the secretion of thyrotropin from… read more here.
Keywords: releasing hormone; thyrotropin; degrading ectoenzyme; thyrotropin releasing ... See more keywords
Identification of the Thyrotropin-Releasing Hormone (TRH) as a Novel Biomarker in the Prognosis for Acute Myeloid Leukemia
Sign Up to like & getrecommendations! Published in 2022 at "Biomolecules"
DOI: 10.3390/biom12101359
Abstract: Acute myeloid leukemia (AML) is a biologically and genetically heterogeneous hematological malignance with an unsatisfactory risk stratification system. Recently, through the novel single-cell RNA sequencing technology, we revealed heterogeneous leukemia myeloblasts in RUNX1-RUNX1T1 AML. Thyrotropin-releasing… read more here.
Keywords: myeloid leukemia; aml; acute myeloid; thyrotropin releasing ... See more keywords
[β-Glu2]TRH Is a Functional Antagonist of Thyrotropin-Releasing Hormone (TRH) in the Rodent Brain
Sign Up to like & getrecommendations! Published in 2021 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms22126230
Abstract: Selective antagonists of thyrotropin-releasing hormone (TRH; pGlu-His-Pro-NH2), in order to enable a better understanding of this peptide’s central functions, have not been identified. Using pGlu-Glu-Pro-NH2 ([Glu2]TRH) as a lead peptide and with modification at its… read more here.
Keywords: releasing hormone; glu2 trh; thyrotropin releasing; trh ... See more keywords