Mechanism of naphthoquinone selectivity of thymidylate synthase ThyX.
Sign Up to like & getrecommendations! Published in 2020 at "Biophysical journal"
DOI: 10.1016/j.bpj.2020.10.042
Abstract: Naphthoquinones (NQs) are natural and synthetic compounds with a wide range of biological activities commonly attributed to their redox activity and/or chemical reactivity. However, genetic and biochemical experiments have recently demonstrated that 2-hydroxy-NQs (2-OH-NQs) act… read more here.
Keywords: thymidylate synthase; thyx; mechanism; synthase thyx ... See more keywords
Structural and functional insight into serine hydroxymethyltransferase from Helicobacter pylori
Sign Up to like & getrecommendations! Published in 2018 at "PLoS ONE"
DOI: 10.1371/journal.pone.0208850
Abstract: Serine hydroxymethyltransferase (SHMT), encoded by the glyA gene, is a ubiquitous pyridoxal 5’-phosphate (PLP)-dependent enzyme that catalyzes the formation of glycine from serine. The thereby generated 5,10-methylene tetrahydrofolate (MTHF) is a major source of cellular… read more here.
Keywords: thyx; serine hydroxymethyltransferase; shmt; functional insight ... See more keywords