Overcoming Resistance to the THZ Series of Covalent Transcriptional CDK Inhibitors.
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DOI: 10.1016/j.chembiol.2017.11.007
Abstract: Irreversible inhibition of transcriptional cyclin-dependent kinases (CDKs) provides a therapeutic strategy for cancers that rely on aberrant transcription; however, lack of understanding of resistance mechanisms to these agents will likely impede their clinical evolution. Here,… read more here.
Keywords: overcoming resistance; covalent; thz series; resistance ... See more keywords