TIA1 Mutations in Amyotrophic Lateral Sclerosis and Frontotemporal Dementia Promote Phase Separation and Alter Stress Granule Dynamics
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DOI: 10.1016/j.neuron.2017.07.025
Abstract: Amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD) are age-related neurodegenerative disorders with shared genetic etiologies and overlapping clinical and pathological features. Here we studied a novel ALS/FTD family and identified the P362L mutation in… read more here.
Keywords: frontotemporal dementia; tia1; stress granule; tia1 mutations ... See more keywords
In Situ Peroxidase Labeling Followed by Mass-Spectrometry Reveals TIA1 Interactome
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DOI: 10.3390/biology11020287
Abstract: Simple Summary T-cell intracellular antigen 1 (TIA1) is a DNA/RNA-binding protein best known for its different roles in RNA metabolism. Currently, little is known about the interacting protein partners of TIA1 in control and stress… read more here.
Keywords: mass spectrometry; stress; tia1; tia1 interactome ... See more keywords
TIA1 Loss Exacerbates Fatty Liver Disease but Exerts a Dual Role in Hepatocarcinogenesis
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DOI: 10.3390/cancers14071704
Abstract: Simple Summary Hepatocellular carcinoma (HCC) is a leading cause of cancer mortality worldwide with few and poorly efficient therapeutic options. Adenylate–uridylate-rich-element-binding proteins (AUBPs) are potent post-transcriptional regulators of gene expression, whose alterations have been associated… read more here.
Keywords: expression; role; hcc; tia1 ... See more keywords