LAUSR

TIA1 Mutations in Amyotrophic Lateral Sclerosis and Frontotemporal Dementia Promote Phase Separation and Alter Stress Granule Dynamics

Sign Up to like & get
recommendations!
0 Published in 2017 at "Neuron"

DOI: 10.1016/j.neuron.2017.07.025

Abstract: Amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD) are age-related neurodegenerative disorders with shared genetic etiologies and overlapping clinical and pathological features. Here we studied a novel ALS/FTD family and identified the P362L mutation in… read more here.

Keywords: frontotemporal dementia; tia1; stress granule; tia1 mutations ... See more keywords