Analysis of Different Binding Modes for Tiagabine within the GAT-1 Transporter
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DOI: 10.3390/biom12111663
Abstract: The recently obtained cryo-electron microscopy structure (PDB code: 7SK2) of the human γ-aminobutyric acid transporter type 1 (hGAT-1) in complex with the antiepileptic drug, tiagabine, revealed a rather unexpected binding mode for this inhibitor in… read more here.
Keywords: open state; transporter; tiagabine; site ... See more keywords
Antiepileptic Drug Tiagabine Does Not Directly Target Key Cardiac Ion Channels Kv11.1, Nav1.5 and Cav1.2
Sign Up to like & getrecommendations! Published in 2021 at "Molecules"
DOI: 10.3390/molecules26123522
Abstract: Tiagabine is an antiepileptic drug used for the treatment of partial seizures in humans. Recently, this drug has been found useful in several non-epileptic conditions, including anxiety, chronic pain and sleep disorders. Since tachycardia—an impairment… read more here.
Keywords: ion channels; drug; ion; tiagabine ... See more keywords