Computer‐directed rational design enhanced the thermostability of carbonyl reductase LsCR for the synthesis of ticagrelor precursor
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DOI: 10.1002/bit.28662
Abstract: Carbonyl reductases are useful for producing optically active alcohols from their corresponding prochiral ketones. Herein, we applied a computer‐assisted strategy to increase the thermostability of a previously constructed carbonyl reductase, LsCRM4 (N101D/A117G/F147L/E145A), which showed an… read more here.
Keywords: synthesis ticagrelor; computer; thermostability; carbonyl ... See more keywords