The TLR3/TICAM-1 signal constitutively controls spontaneous polyposis through suppression of c-Myc in ApcMin/+ mice
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DOI: 10.1186/s12929-017-0387-z
Abstract: BackgroundIntestinal tumorigenesis is promoted by myeloid differentiation primary response gene 88 (MyD88) activation in response to the components of microbiota in ApcMin/+ mice. Microbiota also contains double-stranded RNA (dsRNA), a ligand for TLR3, which activates… read more here.
Keywords: suppression; ticam1 mice; apcmin mice; mice ... See more keywords