Tideglusib enhances odontogenic differentiation in human dental pulp stem cells in vitro.
Sign Up to like & getrecommendations! Published in 2022 at "International endodontic journal"
DOI: 10.1111/iej.13877
Abstract: AIM Tideglusib is a small molecule agonist of the canonical Wnt pathway. The present study investigated the influence of Tideglusib on human dental pulp stem cell (hDPSC) proliferation, apoptosis, migration, and odonto/osteogenic differentiation. METHODOLOGY hDPSCs… read more here.
Keywords: cell; dental pulp; tideglusib; human dental ... See more keywords
GSK-3β Contributes to Parkinsonian Dopaminergic Neuron Death: Evidence From Conditional Knockout Mice and Tideglusib
Sign Up to like & getrecommendations! Published in 2020 at "Frontiers in Molecular Neuroscience"
DOI: 10.3389/fnmol.2020.00081
Abstract: Glycogen synthase kinase-3 (GSK-3) dysregulation has been implicated in nigral dopaminergic neurodegeneration, one of the main pathological features of Parkinson’s disease (PD). The two isoforms, GSK-3α and GSK-3β, have both been suggested to play a… read more here.
Keywords: parkinsonian dopaminergic; death; gsk gsk; mice ... See more keywords
Small Molecule GSK-3 Inhibitors Safely Promote the Proliferation and Viability of Human Dental Pulp Stem Cells—In Vitro
Sign Up to like & getrecommendations! Published in 2023 at "Biomedicines"
DOI: 10.3390/biomedicines11020542
Abstract: Small molecules have demonstrated promising results as successful alternatives to growth factors. In this study, focus was drawn to CHIR99021 and tideglusib as GSK-3 inhibitors known for their anti-inflammatory and regenerative potential. The effect of… read more here.
Keywords: proliferation viability; gsk inhibitors; proliferation; tideglusib ... See more keywords