Therapeutic targeting of the angiopoietin–TIE pathway
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DOI: 10.1038/nrd.2016.278
Abstract: The endothelial angiopoietin (ANG)–TIE growth factor receptor pathway regulates vascular permeability and pathological vascular remodelling during inflammation, tumour angiogenesis and metastasis. Drugs that target the ANG–TIE pathway are in clinical development for oncological and ophthalmological… read more here.
Keywords: tie pathway; targeting angiopoietin; therapeutic targeting; ang tie ... See more keywords
The emerging role of the Angiopoietin-Tie pathway as therapeutic target for treating retinal diseases
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DOI: 10.1080/14728222.2022.2036121
Abstract: ABSTRACT Introduction Several approaches have been investigated for treating wet age-related macular degeneration (w-AMD), diabetic macular edema (DME) and retinal vein occlusions (RVOs). The first-line treatment for these exudative retinal diseases consists of anti-vascular endothelial… read more here.
Keywords: angiopoietin tie; ang tie; tie pathway; retinal diseases ... See more keywords
THE ANGIOPOIETIN/TIE PATHWAY IN RETINAL VASCULAR DISEASES: A REVIEW [67/135 characters].
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DOI: 10.1097/iae.0000000000003003
Abstract: PURPOSE To provide a concise overview for ophthalmologists and practicing retina specialists of available clinical evidence of manipulating the angiopoietin/tyrosine kinase with immunoglobulin-like and endothelial growth factor-like domains (Tie) pathway and its potential as a… read more here.
Keywords: tie pathway; angiopoietin tie; vascular diseases; pathway retinal ... See more keywords
Ang–Tie Angiogenic Pathway Is Distinctively Expressed in Benign and Malignant Adrenocortical Tumors
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DOI: 10.3390/ijms23105579
Abstract: The differential diagnosis between adrenocortical adenomas (ACAs) and adrenocortical carcinomas (ACCs) relies on unspecific clinical, imaging and histological features, and, so far, no single molecular biomarker has proved to improve diagnostic accuracy. Similarly, prognostic factors… read more here.
Keywords: tie angiogenic; adrenocortical tumors; vegf; expression ... See more keywords