Patho-Mechanisms for Hemorrhage/Sepsis-Induced Indirect Acute Respiratory Distress Syndrome: A Role for Lung TIE1 and Its Regulation by Neutrophils
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DOI: 10.1097/shk.0000000000001902
Abstract: ABSTRACT Introduction: Severe hemorrhage (Hem) has been shown to be causal for the development of extra-pulmonary/indirect acute respiratory distress syndrome (iARDS) and is associated with severe endothelial cell (EC) injury. EC growth factors, Angiopoietin (Ang)-1… read more here.
Keywords: role; lung; acute respiratory; tie1 ... See more keywords
Endothelial Tyrosine Kinase Tie1 Is Required for Normal Schlemm’s Canal Development—Brief Report
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DOI: 10.1161/atvbaha.121.316692
Abstract: Background: Schlemm’s canal (SC) is a large vessel residing in the iridocorneal angle and is required to regulate aqueous humor outflow. Normal SC structure and function is indispensable for maintaining normal intraocular pressure, and elevated… read more here.
Keywords: function; development; intraocular pressure; schlemm canal ... See more keywords
Preclinical validation of a novel metastasis‐inhibiting Tie1 function‐blocking antibody
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DOI: 10.15252/emmm.201911164
Abstract: The angiopoietin (Ang)–Tie pathway has been intensely pursued as candidate second‐generation anti‐angiogenic target. While much of the translational work has focused on the ligand Ang2, the clinical efficacy of Ang2‐targeting drugs is limited and failed… read more here.
Keywords: function blocking; metastasis; tie1; tie1 function ... See more keywords