Imaging of Tie2 with a fluorescently labeled small molecule affinity ligand.
Sign Up to like & getrecommendations! Published in 2019 at "ACS chemical biology"
DOI: 10.1021/acschembio.9b00724
Abstract: The receptor tyrosine kinase inhibitor, Tie2, has significant roles in endothelial signaling and angiogenesis, and is relevant in the pathophysiology of several diseases. However, there are relatively few small molecule probes available to study Tie2,… read more here.
Keywords: small molecule; tie2 fluorescently; imaging tie2; tie2 ... See more keywords
Tie2-expressing monocytes/macrophages promote cerebral revascularization in peri-infarct lesions upon ischemic insult
Sign Up to like & getrecommendations! Published in 2021 at "Signal Transduction and Targeted Therapy"
DOI: 10.1038/s41392-021-00637-w
Abstract: Dear Editor, Strokes cause 5.8 million deaths each year. Among these victims, ~30% are from China. Acute ischemic stroke (AIS) is the most prevalent subtype of strokes. Although drugs can alleviate the symptoms, the recoveries… read more here.
Keywords: supplementary fig; blood; cd14; fig ... See more keywords
Molecular Regulation of Acute Tie2 Suppression in Sepsis
Sign Up to like & getrecommendations! Published in 2018 at "Critical Care Medicine"
DOI: 10.1097/ccm.0000000000003269
Abstract: Objectives: Tie2 is a tyrosine kinase receptor expressed by endothelial cells that maintains vascular barrier function. We recently reported that diverse critical illnesses acutely decrease Tie2 expression and that experimental Tie2 reduction suffices to recapitulate… read more here.
Keywords: suppression; tie2 messenger; tie2 suppression; endothelial cells ... See more keywords
150 A high throughput sirna screening identifies rac1 as a potential modulator of the endocytosis of the tyrosine kinase receptor tie2
Sign Up to like & getrecommendations! Published in 2017 at "Heart"
DOI: 10.1136/heartjnl-2017-311726.149
Abstract: Angiogenesis, Tie2, Endocytosis The Tie2 receptor is a cell surface tyrosine kinase receptor expressed almost exclusively in endothelial cells, where it is mainly implicated in angiogenesis. Indeed, Tie2 has been related to various pathologies with… read more here.
Keywords: internalisation; endocytosis; receptor; tie2 ... See more keywords
Aliskiren Improved the Endothelial Repair Capacity of Endothelial Progenitor Cells from Patients with Hypertension via the Tie2/PI3k/Akt/eNOS Signalling Pathway
Sign Up to like & getrecommendations! Published in 2020 at "Cardiology Research and Practice"
DOI: 10.1155/2020/6534512
Abstract: Background Studies show that aliskiren exerts favourable effects not only on endothelial progenitor cells (EPCs) but also on endothelial function. However, the mechanism of the favourable effect of aliskiren on EPCs from patients with hypertension… read more here.
Keywords: tie2; signalling pathway; endothelial progenitor; hypertension ... See more keywords
Tie2 Receptor in Tumor-Infiltrating Macrophages Is Dispensable for Tumor Angiogenesis and Tumor Relapse after Chemotherapy
Sign Up to like & getrecommendations! Published in 2022 at "Cancer Research"
DOI: 10.1158/0008-5472.can-21-3181
Abstract: Multiple preclinical tumor models, cell stimulation experiments, and meta-analysis of published tumor single cell RNA sequencing data challenge the reported role of Tie2-positive macrophages for tumor angiogenesis, metastasis, and relapse after chemotherapy. read more here.
Keywords: tie2; tumor; tumor angiogenesis; relapse chemotherapy ... See more keywords
Pattern of tamoxifen-induced Tie2 deletion in endothelial cells in mature blood vessels using endo SCL-Cre-ERT transgenic mice
Sign Up to like & getrecommendations! Published in 2022 at "PLoS ONE"
DOI: 10.1371/journal.pone.0268986
Abstract: Tyrosine-protein kinase receptor Tie2, also known as Tunica interna Endothelial cell Kinase or TEK plays a prominent role in endothelial responses to angiogenic and inflammatory stimuli. Here we generated a novel inducible Tie2 knockout mouse… read more here.
Keywords: tie2; cre; cre ert; scl cre ... See more keywords
Utilizing combinatorial engineering to develop Tie2 targeting antagonistic angiopoetin-2 ligands as candidates for anti-angiogenesis therapy
Sign Up to like & getrecommendations! Published in 2017 at "Oncotarget"
DOI: 10.18632/oncotarget.16827
Abstract: In many human cancers, the receptor tyrosine kinase (RTK) Tie2 plays important roles in mediating proliferation, survival, migration and angiogenesis. Thus, molecules that could potently inhibit activation of the Tie2 receptor would have a significant… read more here.
Keywords: utilizing combinatorial; engineering; develop tie2; angiogenesis ... See more keywords