Desuppression of TGF-β signaling via nuclear c-Abl-mediated phosphorylation of TIF1γ/TRIM33 at Tyr-524, -610, and -1048
Sign Up to like & getrecommendations! Published in 2018 at "Oncogene"
DOI: 10.1038/s41388-018-0481-z
Abstract: Protein-tyrosine kinases regulate a broad range of intracellular processes occurring primarily just beneath the plasma membrane. With the greatest care to prevent dephosphorylation, we have shown that nuclear tyrosine phosphorylation regulates global chromatin structural states.… read more here.
Keywords: phosphorylation tif1; tgf signaling; tyrosine phosphorylation; tif1 ... See more keywords
Cell-specific transcriptional control of mitochondrial metabolism by TIF1γ drives erythropoiesis
Sign Up to like & getrecommendations! Published in 2021 at "Science"
DOI: 10.1126/science.aaz2740
Abstract: Metabolic pathway regulates cell fate Lineage-specific regulators direct cell fate decisions, but the precise mechanisms are not well known. Using an in vivo chemical suppressor screen of a bloodless zebrafish mutant, Rossmann et al. show… read more here.
Keywords: tif1; cell fate; mitochondrial metabolism; factor ... See more keywords
Abstract PR04: Transcriptional regulation of mitochondrial metabolism by TIF1γ drives erythroid progenitor differentiation
Sign Up to like & getrecommendations! Published in 2020 at "Cancer Research"
DOI: 10.1158/1538-7445.epimetab20-pr04
Abstract: Understanding in-vivo mechanisms of erythropoiesis is critical for directed differentiation approaches to treat blood disorders such as leukemias. Zebrafish moonshine (mon) mutant embryos defective for the conserved transcriptional intermediary factor 1 gamma (tif1γ) do not… read more here.
Keywords: regulation mitochondrial; tif1; differentiation; mitochondrial metabolism ... See more keywords
A Commercial Anti-TIF1γ ELISA Is Superior to Line and Dot Blot and Should Be Considered as Part of Routine Myositis-Specific Antibody Testing
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Immunology"
DOI: 10.3389/fimmu.2022.804037
Abstract: Objectives Anti-TIF1γ is an important autoantibody in the diagnosis of cancer-associated dermatomyositis and the most common autoantibody in juvenile onset dermatomyositis. Its reliable detection is important to instigate further investigations into underlying malignancy in adults.… read more here.
Keywords: tif1; anti tif1; line dot; autoantibody ... See more keywords