Binding and Enhanced Binding between Key Immunity Proteins TRAF6 and TIFA
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DOI: 10.1002/cbic.201800436
Abstract: Human tumor necrosis factor receptor associated factor (TRAF)‐interacting protein, with a forkhead‐associated domain (TIFA), is a key regulator of NF‐κB activation. It also plays a key role in the activation of innate immunity in response… read more here.
Keywords: immunity; enhanced binding; binding; tifa ... See more keywords
Structural analysis of TIFA: Insight into TIFA-dependent signal transduction in innate immunity
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DOI: 10.1038/s41598-020-61972-6
Abstract: TRAF-interacting protein with a forkhead-associated (FHA) domain (TIFA), originally identified as an adaptor protein of TRAF6, has recently been shown to be involved in innate immunity, induced by a pathogen-associated molecular pattern (PAMP). ADP-β-D-manno-heptose, a… read more here.
Keywords: traf6; tifa dependent; analysis; tifa traf6 ... See more keywords
Akkermansia muciniphila upregulates genes involved in maintaining the intestinal barrier function via ADP-heptose-dependent activation of the ALPK1/TIFA pathway
Sign Up to like & getrecommendations! Published in 2022 at "Gut Microbes"
DOI: 10.1080/19490976.2022.2110639
Abstract: ABSTRACT The commensal bacteria that make up the gut microbiota impact the health of their host on multiple levels. In particular, the interactions taking place between the microbe-associated molecule patterns (MAMPs) and pattern recognition receptors… read more here.
Keywords: tifa; adp heptose; akkermansia muciniphila; genes involved ... See more keywords
TIFA Signaling in Gastric Epithelial Cells Initiates the cag Type 4 Secretion System-Dependent Innate Immune Response to Helicobacter pylori Infection
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DOI: 10.1128/mbio.01168-17
Abstract: ABSTRACT Helicobacter pylori is a bacterial pathogen that colonizes the human stomach, causing inflammation which, in some cases, leads to gastric ulcers and cancer. The clinical outcome of infection depends on a complex interplay of… read more here.
Keywords: epithelial cells; gastric epithelial; response; tifa ... See more keywords
The potential biomarker TIFA regulates pyroptosis in sepsis-induced acute kidney injury.
Sign Up to like & getrecommendations! Published in 2022 at "International immunopharmacology"
DOI: 10.2139/ssrn.4210370
Abstract: Sepsis is the leading cause of acute kidney injury (AKI), and specific treatment options for septic AKI are very limited. Here, we used bulk RNA sequencing of a septic model of AKI to characterize the… read more here.
Keywords: tifa; sepsis induced; kidney injury; sepsis ... See more keywords