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   Articles with "tigar" as a keyword



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Knockout of TIGAR enhances myocardial phosphofructokinase activity and preserves diastolic function in heart failure

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recommendations! Published in 2022 at "Journal of Cellular Physiology"

DOI: 10.1002/jcp.30790

Abstract: Hypertension is an important risk factor in the pathogenesis of diastolic dysfunction. Growing evidence indicates that glucose metabolism plays an essential role in diastolic dysfunction. TP53‐induced glycolysis and apoptosis regulator (TIGAR) has been shown to… read more here.

Keywords: tigar; heart failure; knockout tigar; diastolic dysfunction ... See more keywords
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In silico identification of potential inhibitor for TP53-induced glycolysis and apoptosis regulator in head and neck squamous cell carcinoma

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recommendations! Published in 2021 at "3 Biotech"

DOI: 10.1007/s13205-021-02665-3

Abstract: Head and neck squamous cell carcinoma (HNSCC) is the six most common cancer globally and most common cancer in men in India. The metabolic regulation is highly altered and is considered as a hall mark… read more here.

Keywords: glycolysis apoptosis; tp53 induced; apoptosis regulator; induced glycolysis ... See more keywords
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Dynamic ROS Regulation by TIGAR: Balancing Anti-cancer and Pro-metastasis Effects.

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recommendations! Published in 2020 at "Cancer cell"

DOI: 10.1016/j.ccell.2020.01.009

Abstract: The role of ROS in cancer is complex, with studies demonstrating both pro- and anti-tumor effects. In a pancreatic ductal adenocarcinoma model, ROS limitation through TIGAR has been shown to initially support cancer development but… read more here.

Keywords: tigar; ros regulation; tigar balancing; cancer ... See more keywords
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Targeting neuroinflammation to treat cerebral ischemia - The role of TIGAR/NADPH axis

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recommendations! Published in 2021 at "Neurochemistry International"

DOI: 10.1016/j.neuint.2021.105081

Abstract: Cerebral ischemia is a disease of ischemic necrosis of brain tissue caused by intracranial artery stenosis or occlusion and cerebral artery embolization. Neuroinflammation plays an important role in the pathophysiology of cerebral ischemia. Microglia, astrocytes,… read more here.

Keywords: cerebral ischemia; neuroinflammation; role; tigar ... See more keywords
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The E3 ubiquitin ligase TRIM31 is involved in cerebral ischemic injury by promoting degradation of TIGAR

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recommendations! Published in 2021 at "Redox Biology"

DOI: 10.1016/j.redox.2021.102058

Abstract: Tripartite motif (TRIM) 31 has been implicated in diverse biological and pathological conditions. However, whether TRIM31 plays a role in ischemic stroke progression is not clarified. Here we demonstrated that TRIM31 was significantly downregulated in… read more here.

Keywords: trim31; ubiquitin ligase; brain; tigar ... See more keywords
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Structure, regulation, and biological functions of TIGAR and its role in diseases.

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recommendations! Published in 2021 at "Acta pharmacologica Sinica"

DOI: 10.1038/s41401-020-00588-y

Abstract: TIGAR (TP53-induced glycolysis and apoptosis regulator) is the downstream target gene of p53, contains a functional sequence similar to 6-phosphofructose kinase/fructose-2, 6-bisphosphatase (PFKFB) bisphosphatase domain. TIGAR is mainly located in the cytoplasm; in response to… read more here.

Keywords: regulation biological; functions tigar; biological functions; tigar role ... See more keywords
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Abstract 563: Cardiac TIGAR Reduces Myocardial Energetics and Cardiac Functionin the Pressure Overload Heart Failure Model

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recommendations! Published in 2019 at "Circulation Research"

DOI: 10.1161/res.125.suppl_1.563

Abstract: Background: Although metabolic alterations were observed in heart failure (HF), only recently have the mechanisms underlying these changes been identified. Tumor suppressor p53 responds to metabolic changes thorough several mechanisms. One of the p53 targets,… read more here.

Keywords: heart; pressure overload; mice; tigar ... See more keywords

TIGAR deficiency induces caspase-1-dependent trophoblasts pyroptosis through NLRP3-ASC inflammasome

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recommendations! Published in 2023 at "Frontiers in Immunology"

DOI: 10.3389/fimmu.2023.1114620

Abstract: Introduction Gestational diabetes mellitus (GDM), a common complication of pregnancy, is risky for both mother and fetus. Previous studies about TP53-induced glycolysis and apoptosis regulator (TIGAR) focused on the occurrence and development of cancer, cardiovascular… read more here.

Keywords: tigar; pyroptosis; asc inflammasome; nlrp3 asc ... See more keywords
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The role of TIGAR in nervous system diseases

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recommendations! Published in 2022 at "Frontiers in Aging Neuroscience"

DOI: 10.3389/fnagi.2022.1023161

Abstract: TP53-induced glycolysis and apoptosis regulator (TIGAR) mainly regulates pentose phosphate pathway by inhibiting glycolysis, so as to synthesize ribose required by DNA, promote DNA damage repair and cell proliferation, maintain cell homeostasis and avoid body… read more here.

Keywords: tigar; role tigar; system diseases; nervous system ... See more keywords
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The Expression of TP53-Induced Glycolysis and Apoptosis Regulator (TIGAR) Can Be Controlled by the Antioxidant Orchestrator NRF2 in Human Carcinoma Cells

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recommendations! Published in 2022 at "International Journal of Molecular Sciences"

DOI: 10.3390/ijms23031905

Abstract: Hyperactivation of the KEAP1-NRF2 axis is a common molecular trait in carcinomas from different origin. The transcriptional program induced by NRF2 involves antioxidant and metabolic genes that render cancer cells more capable of dealing with… read more here.

Keywords: induced glycolysis; expression; tp53 induced; regulator ... See more keywords

Inhibition of TIGAR Increases Exogenous p53 and Cisplatin Combination Sensitivity in Lung Cancer Cells by Regulating Glycolytic Flux

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recommendations! Published in 2022 at "International Journal of Molecular Sciences"

DOI: 10.3390/ijms232416034

Abstract: The metabolism and apoptosis of tumor cells are important factors that increase their sensitivity to chemotherapeutic drugs. p53 and cisplatin not only induce tumor cell apoptosis, but also regulate the tumor cell metabolism. The TP53-induced… read more here.

Keywords: tigar; p53 cisplatin; sensitivity; flux ... See more keywords