Emerging High‐Level Tigecycline Resistance: Novel Tetracycline Destructases Spread via the Mobile Tet(X)
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DOI: 10.1002/bies.202000014
Abstract: Antibiotic resistance in bacteria has become a great threat to global public health. Tigecycline is a next‐generation tetracycline that is the final line of defense against severe infections by pan‐drug‐resistant bacterial pathogens. Unfortunately, this last‐resort… read more here.
Keywords: tigecycline resistance; high level; tigecycline; mobile tet ... See more keywords
Preliminary experience with tigecycline treatment for severe infection in children
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DOI: 10.1007/s00431-018-3208-9
Abstract: Severe infection is a primary cause of mortality in children facing challenges from multidrug-resistant (MDR) pathogens, particularly MDR Acinetobacter baumannii. Tigecycline has an expanded spectrum of antibacterial activity, and some successful instances of its use… read more here.
Keywords: improvement; tigecycline; treatment; infection ... See more keywords
Tigecycline salvage therapy for ventriculoperitoneal shunt meningitis due to extensively drug-resistant Acinetobacter baumannii
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DOI: 10.1007/s00431-018-3271-2
Abstract: To the Editor, We read with great interest the article by Ye et al. [3] regarding tigecycline treatment for severe infection in children. In this cohort, only one patient with meningitis received tigecycline without clinical… read more here.
Keywords: meningitis; tigecycline; treatment; extensively drug ... See more keywords
Antibiotic tigecycline enhances cisplatin activity against human hepatocellular carcinoma through inducing mitochondrial dysfunction and oxidative damage.
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DOI: 10.1016/j.bbrc.2017.01.021
Abstract: Targeting mitochondrial metabolism has been recently demonstrated to be a promising therapeutic strategy for the treatment of various cancer. In this work, we demonstrate that antibiotic tigecycline is selectively against hepatocellular carcinoma (HCC) through inducing… read more here.
Keywords: oxidative damage; hcc; tigecycline; mitochondrial dysfunction ... See more keywords
Antimicrobial activity among gram-positive and gram-negative organisms collected from the Asia-Pacific region as part of the Tigecycline Evaluation and Surveillance Trial: Comparison of 2015 results with previous years.
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DOI: 10.1016/j.diagmicrobio.2017.08.014
Abstract: We report the in vitro activity of tigecycline and comparators against Gram-negative and Gram-positive organisms collected from Asia-Pacific during 2004-2010 and 2015. MICs were determined by broth microdilution using CLSI guidelines. Antimicrobial susceptibility was assessed… read more here.
Keywords: asia pacific; gram positive; tigecycline; gram negative ... See more keywords
Surveillance of tigecycline activity tested against clinical isolates from a global (North America, Europe, Latin America and Asia-Pacific) collection (2016).
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DOI: 10.1016/j.ijantimicag.2018.01.006
Abstract: Tigecycline and comparators were tested by the reference broth microdilution method against 33 348 non-duplicate bacterial isolates collected prospectively in 2016 from medical centres in the Asia-Pacific (3443 isolates), Europe (13 530 isolates), Latin America… read more here.
Keywords: asia pacific; tigecycline; mic50; latin america ... See more keywords
In vitro activity of tigecycline and comparators (2014-2016) among key WHO 'priority pathogens' and longitudinal assessment (2004-2016) of antimicrobial resistance: a report from the T.E.S.T. study.
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DOI: 10.1016/j.ijantimicag.2018.07.003
Abstract: We report contemporary (2014-2016) Tigecycline Evaluation and Surveillance Trial (T.E.S.T.) global data on activity of tigecycline and comparators against WHO 'priority pathogens', and global trends (2004-2016) in antimicrobial resistance. MICs were determined using CLSI broth… read more here.
Keywords: 2014 2016; tigecycline; resistance; south america ... See more keywords
The influence of age on the clinical efficacy of tigecycline in severely ill patients.
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DOI: 10.1016/j.jgar.2019.03.018
Abstract: OBJECTIVES This analysis aimed to define the relationship between age and response to tigecycline among patients treated for complicated skin and soft tissue infections (cSSTI) and complicated intra-abdominal infections (cIAI). METHODS Pooled data derived from… read more here.
Keywords: tigecycline; age; influence age; cssti ciai ... See more keywords
Preparation, characterization, and antibacterial activity of tigecycline-loaded, ultrasound-activated microbubbles
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DOI: 10.1080/10837450.2021.2017967
Abstract: Abstract Central nervous system infectious disease caused by the multidrug-resistant Acinetobacter baumannii (AB) seriously threatens human life in clinic. Tigecycline has good sensitivity in killing AB, but due to its wide tissue distribution and blood-brain… read more here.
Keywords: loaded ultrasound; antibacterial activity; preparation; tigecycline ... See more keywords
Tigecycline treatment causes a decrease in peripheral blood platelet.
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DOI: 10.1080/1120009x.2022.2153315
Abstract: Tigecycline with broad-spectrum activity against pathogens has advantages in the treatment of severe infections in clinical. Accompany with the huge increase of tigecycline usage, more side effects began to arouse people's attention. The aim of… read more here.
Keywords: tigecycline treatment; tigecycline; blood platelet; peripheral blood ... See more keywords
A Snapshot of Co-Resistance to Carbapenems and Tigecycline in Clinical Isolates of Enterobacter cloacae.
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DOI: 10.1089/mdr.2015.0311
Abstract: Enterobacter cloacae is one of the most common carbapenem-resistant Enterobacteriaceae (CRE) global wide. Resistance to tigecycline, one of the few therapeutic options for CRE infections, in carbapenem-resistant E. cloacae is of clinical significance. Fourteen E.… read more here.
Keywords: tigecycline; resistance; clinical isolates; enterobacter cloacae ... See more keywords