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Published in 2020 at "BioEssays"
DOI: 10.1002/bies.202000014
Abstract: Antibiotic resistance in bacteria has become a great threat to global public health. Tigecycline is a next‐generation tetracycline that is the final line of defense against severe infections by pan‐drug‐resistant bacterial pathogens. Unfortunately, this last‐resort…
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Keywords:
tigecycline resistance;
high level;
tigecycline;
mobile tet ... See more keywords
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Published in 2021 at "International journal of antimicrobial agents"
DOI: 10.1016/j.ijantimicag.2021.106304
Abstract: Tigecycline resistance remains rare in S. aureus worldwide. Twelve TGC resistant S. aureus mutants (TRSAm) were obtained displaying an increase in their efflux activity. The isolates belonged to 7 different genetic lineages, with predominance of CC5. Diverse genetic changes in…
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Keywords:
tigecycline resistance;
amino acid;
resistance;
genetic changes ... See more keywords
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Published in 2019 at "Microbial drug resistance"
DOI: 10.1089/mdr.2019.0346
Abstract: Tigecycline-resistant enterococci are only rarely detected worldwide. In 2017, the National Reference Centre for Staphylococci and Enterococci noticed a nosocomial cluster of tigecycline- and vancomycin-resistant Enterococcus faecium (TVRE) in a hospital of tertiary care in…
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Keywords:
tigecycline resistance;
tigecycline;
nosocomial cluster;
resistance ... See more keywords
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Published in 2021 at "Environmental microbiology"
DOI: 10.1111/1462-2920.15632
Abstract: The transferability of bacterial resistance to tigecycline, the 'last-resort' antibiotic, is an emerging challenge of global health concern. The plasmid-borne tet(X) that encodes a flavin-dependent monooxygenase represents a new mechanism for tigecycline resistance. Natural source…
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Keywords:
tigecycline resistance;
poultry pathogen;
resistance;
pathogen riemerella ... See more keywords
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Published in 2017 at "Antimicrobial Agents and Chemotherapy"
DOI: 10.1128/aac.00391-17
Abstract: ABSTRACT Tigecycline is regarded as a last-resort treatment for carbapenem-resistant Klebsiella pneumoniae (CRKP) infections, but increasing numbers of tigecycline-resistant K. pneumoniae isolates have been reported. The tigecycline resistance mechanisms in CRKP are undetermined. This study…
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Keywords:
tigecycline resistance;
tigecycline;
pneumoniae;
carbapenem resistant ... See more keywords
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Published in 2021 at "Antimicrobial Agents and Chemotherapy"
DOI: 10.1128/aac.02084-20
Abstract: The plasmid-mediated tet(X7) conferring high-level tigecycline resistance was identified in five mcr-1.1-positive Escherichia coli strains (ST10 [n = 3] and ST155 [n = 2]) isolated from chickens in Egypt. Two fosfomycin-resistant fosA4-carrying IncFII plasmids (⁓79 kb in size) were detected.…
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Keywords:
tet conferring;
level tigecycline;
tigecycline resistance;
conferring high ... See more keywords
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Published in 2022 at "Microbiology Spectrum"
DOI: 10.1128/spectrum.00732-22
Abstract: Emergence of pathogens harboring tigecycline resistance genes incurs great concerns. Wastewater is recognized as the important reservoir of antimicrobial resistance genes. Here we characterized the phenotypes and genotypes of bacteria carrying tet(X4) from wastewater in…
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Keywords:
tigecycline resistance;
wastewater turkey;
resistance;
tet ... See more keywords
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Published in 2022 at "Microbiology Spectrum"
DOI: 10.1128/spectrum.03468-22
Abstract: Tigecycline is regarded as one of the few effective drugs against multidrug-resistant bacterial infection. However, mobile tigecycline resistance efflux pump gene clusters such as tmexC1D1-toprJ1 and its variants have been identified in both animal- and…
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Keywords:
tigecycline resistance;
resistance;
efflux pump;
tmexc2d2 toprj2 ... See more keywords
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Published in 2021 at "Frontiers in Microbiology"
DOI: 10.3389/fmicb.2021.674502
Abstract: Tigecycline is a last-resort antibiotic for infections caused by carbapenem-resistant Klebsiella pneumoniae (CRKP). This study aimed to broaden our understanding of the acquisition of collateral hypersensitivity by CRKP, as an evolutionary trade-off of developing resistance…
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Keywords:
tigecycline resistance;
tigecycline;
resistance;
carbapenem resistant ... See more keywords
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Published in 2022 at "Frontiers in Microbiology"
DOI: 10.3389/fmicb.2022.969769
Abstract: With the large-scale use of antibiotics, antibiotic resistant bacteria (ARB) continue to rise, and antibiotic resistance genes (ARGs) are regarded as emerging environmental pollutants. The new tetracycline-class antibiotic, tigecycline is the last resort for treating…
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Keywords:
tigecycline resistance;
plasmid mediated;
resistance gene;
resistance ... See more keywords
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Published in 2022 at "Antibiotics"
DOI: 10.3390/antibiotics11050572
Abstract: Mycobacteroides abscessus (formerly Mycobacterium abscessus) is a clinically important, rapid-growing non-tuberculous mycobacterium notoriously known for its multidrug-resistance phenotype. The intrinsic resistance of M. abscessus towards first- and second-generation tetracyclines is mainly due to the over-expression…
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Keywords:
mycobacteroides abscessus;
genetic determinants;
resistance;
tigecycline resistance ... See more keywords