Emerging High‐Level Tigecycline Resistance: Novel Tetracycline Destructases Spread via the Mobile Tet(X)
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DOI: 10.1002/bies.202000014
Abstract: Antibiotic resistance in bacteria has become a great threat to global public health. Tigecycline is a next‐generation tetracycline that is the final line of defense against severe infections by pan‐drug‐resistant bacterial pathogens. Unfortunately, this last‐resort… read more here.
Keywords: tigecycline resistance; high level; tigecycline; mobile tet ... See more keywords
Genetic changes associated to tigecycline resistance in Staphylococcus aureus in-vitro selected mutants belonging to different lineages: Genetic changes in S. aureus mutants resistant to tigecycline.
Sign Up to like & getrecommendations! Published in 2021 at "International journal of antimicrobial agents"
DOI: 10.1016/j.ijantimicag.2021.106304
Abstract: Tigecycline resistance remains rare in S. aureus worldwide. Twelve TGC resistant S. aureus mutants (TRSAm) were obtained displaying an increase in their efflux activity. The isolates belonged to 7 different genetic lineages, with predominance of CC5. Diverse genetic changes in… read more here.
Keywords: tigecycline resistance; amino acid; resistance; genetic changes ... See more keywords
A Nosocomial Cluster of Tigecycline- and Vancomycin-Resistant Enterococcus faecium Isolates and the Impact of rpsJ and tet(M) Mutations on Tigecycline Resistance.
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DOI: 10.1089/mdr.2019.0346
Abstract: Tigecycline-resistant enterococci are only rarely detected worldwide. In 2017, the National Reference Centre for Staphylococci and Enterococci noticed a nosocomial cluster of tigecycline- and vancomycin-resistant Enterococcus faecium (TVRE) in a hospital of tertiary care in… read more here.
Keywords: tigecycline resistance; tigecycline; nosocomial cluster; resistance ... See more keywords
The Poultry Pathogen Riemerella anatipestifer Appears as a Reservoir for Tet(X) Tigecycline Resistance.
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DOI: 10.1111/1462-2920.15632
Abstract: The transferability of bacterial resistance to tigecycline, the 'last-resort' antibiotic, is an emerging challenge of global health concern. The plasmid-borne tet(X) that encodes a flavin-dependent monooxygenase represents a new mechanism for tigecycline resistance. Natural source… read more here.
Keywords: tigecycline resistance; poultry pathogen; resistance; pathogen riemerella ... See more keywords
Roles of ramR and tet(A) Mutations in Conferring Tigecycline Resistance in Carbapenem-Resistant Klebsiella pneumoniae Clinical Isolates
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DOI: 10.1128/aac.00391-17
Abstract: ABSTRACT Tigecycline is regarded as a last-resort treatment for carbapenem-resistant Klebsiella pneumoniae (CRKP) infections, but increasing numbers of tigecycline-resistant K. pneumoniae isolates have been reported. The tigecycline resistance mechanisms in CRKP are undetermined. This study… read more here.
Keywords: tigecycline resistance; tigecycline; pneumoniae; carbapenem resistant ... See more keywords
Coproduction of Tet(X7) Conferring High-Level Tigecycline Resistance, Fosfomycin FosA4, and Colistin Mcr-1.1 in Escherichia coli Strains from Chickens in Egypt
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DOI: 10.1128/aac.02084-20
Abstract: The plasmid-mediated tet(X7) conferring high-level tigecycline resistance was identified in five mcr-1.1-positive Escherichia coli strains (ST10 [n = 3] and ST155 [n = 2]) isolated from chickens in Egypt. Two fosfomycin-resistant fosA4-carrying IncFII plasmids (⁓79 kb in size) were detected.… read more here.
Keywords: tet conferring; level tigecycline; tigecycline resistance; conferring high ... See more keywords
Emergence and Characterization of Tigecycline Resistance Gene tet(X4) in ST609 Escherichia coli Isolates from Wastewater in Turkey
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DOI: 10.1128/spectrum.00732-22
Abstract: Emergence of pathogens harboring tigecycline resistance genes incurs great concerns. Wastewater is recognized as the important reservoir of antimicrobial resistance genes. Here we characterized the phenotypes and genotypes of bacteria carrying tet(X4) from wastewater in… read more here.
Keywords: tigecycline resistance; wastewater turkey; resistance; tet ... See more keywords
Multiple Copies of Mobile Tigecycline Resistance Efflux Pump Gene Cluster tmexC2D2.2-toprJ2 Identified in Chromosome of Aeromonas spp.
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DOI: 10.1128/spectrum.03468-22
Abstract: Tigecycline is regarded as one of the few effective drugs against multidrug-resistant bacterial infection. However, mobile tigecycline resistance efflux pump gene clusters such as tmexC1D1-toprJ1 and its variants have been identified in both animal- and… read more here.
Keywords: tigecycline resistance; resistance; efflux pump; tmexc2d2 toprj2 ... See more keywords
Acquisition of Tigecycline Resistance by Carbapenem-Resistant Klebsiella pneumoniae Confers Collateral Hypersensitivity to Aminoglycosides
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DOI: 10.3389/fmicb.2021.674502
Abstract: Tigecycline is a last-resort antibiotic for infections caused by carbapenem-resistant Klebsiella pneumoniae (CRKP). This study aimed to broaden our understanding of the acquisition of collateral hypersensitivity by CRKP, as an evolutionary trade-off of developing resistance… read more here.
Keywords: tigecycline resistance; tigecycline; resistance; carbapenem resistant ... See more keywords
Dissemination and prevalence of plasmid-mediated high-level tigecycline resistance gene tet (X4)
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Microbiology"
DOI: 10.3389/fmicb.2022.969769
Abstract: With the large-scale use of antibiotics, antibiotic resistant bacteria (ARB) continue to rise, and antibiotic resistance genes (ARGs) are regarded as emerging environmental pollutants. The new tetracycline-class antibiotic, tigecycline is the last resort for treating… read more here.
Keywords: tigecycline resistance; plasmid mediated; resistance gene; resistance ... See more keywords
Genetic Determinants of Tigecycline Resistance in Mycobacteroides abscessus
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DOI: 10.3390/antibiotics11050572
Abstract: Mycobacteroides abscessus (formerly Mycobacterium abscessus) is a clinically important, rapid-growing non-tuberculous mycobacterium notoriously known for its multidrug-resistance phenotype. The intrinsic resistance of M. abscessus towards first- and second-generation tetracyclines is mainly due to the over-expression… read more here.
Keywords: mycobacteroides abscessus; genetic determinants; resistance; tigecycline resistance ... See more keywords