Culture of Intestinal Epithelial Cell Monolayers and Their Use in Multiplex Macromolecular Permeability Assays for In Vitro Analysis of Tight Junction Size Selectivity
Sign Up to like & getrecommendations! Published in 2020 at "Current Protocols in Immunology"
DOI: 10.1002/cpim.112
Abstract: Tight junctions form a selectively permeable barrier that limits paracellular flux across epithelial‐lined surfaces. Small molecules (less than ∼8 Å diameter) can traverse the junction via the size‐ and charge‐selective, high‐conductance pore pathway. In contrast,… read more here.
Keywords: epithelial cell; intestinal epithelial; cell monolayers; size ... See more keywords
N‐(3‐oxododecanoyl)‐l‐homoserine lactone disrupts intestinal epithelial barrier through triggering apoptosis and collapsing extracellular matrix and tight junction
Sign Up to like & getrecommendations! Published in 2021 at "Journal of Cellular Physiology"
DOI: 10.1002/jcp.30261
Abstract: Microbes employ autoinducers of quorum sensing (QS) for population communication. Although the autoinducer of Pseudomonas aeruginosa LasI‐LasR system, N‐(3‐oxododecanoyl)‐ l‐homoserine lactone (3OC12), has been reported with deleterious effects on host cells, its biological effects on… read more here.
Keywords: intestinal epithelial; 3oc12 3oc14; apoptosis; epithelial barrier ... See more keywords
Mammary gland cell’s tight junction permeability from dairy cows producing stable or unstable milk in the ethanol test
Sign Up to like & getrecommendations! Published in 2020 at "International Journal of Biometeorology"
DOI: 10.1007/s00484-020-01967-0
Abstract: Tight junctions are almost impermeable structures located near the apical border of epithelial cells; increase in the permeability of mammary gland cells’ tight junctions may alter milk composition and its suitability for industrialization. Sixteen Holstein… read more here.
Keywords: milk; permeability; mammary gland; unstable milk ... See more keywords
Myosin IIA Regulated Tight Junction in Oxygen Glucose-Deprived Brain Endothelial Cells Via Activation of TLR4/PI3K/Akt/JNK1/2/14-3-3ε/NF-κB/MMP9 Signal Transduction Pathway
Sign Up to like & getrecommendations! Published in 2019 at "Cellular and Molecular Neurobiology"
DOI: 10.1007/s10571-019-00654-y
Abstract: Non-muscle myosin heavy chain IIA (NMMHC IIA), a member of Myosin II family, plays a critical role in various cellular physiological processes. Our previous research had suggested that NMMHC IIA could participate in regulating tight… read more here.
Keywords: transduction pathway; nmmhc iia; endothelial cells; junction ... See more keywords
Genetic Variation and Gene Expression Levels of Tight Junction Genes Indicates Relationships Between PTEN as well as MAGI1 and Microscopic Colitis
Sign Up to like & getrecommendations! Published in 2017 at "Digestive Diseases and Sciences"
DOI: 10.1007/s10620-017-4857-7
Abstract: Background and AimMicroscopic colitis (MC) has been associated with increased paracellular permeability. Therefore, we aimed to investigate potential associations between MC and several genes encoding tight junction (TJ) proteins reported to interact with each other.MethodsThe… read more here.
Keywords: gene expression; association; colitis; expression ... See more keywords
Blood-Brain Barrier Permeability Is Exacerbated in Experimental Model of Hepatic Encephalopathy via MMP-9 Activation and Downregulation of Tight Junction Proteins
Sign Up to like & getrecommendations! Published in 2017 at "Molecular Neurobiology"
DOI: 10.1007/s12035-017-0521-7
Abstract: The present study was designed to investigate the mechanisms involved in blood-brain barrier (BBB) permeability in bile duct ligation (BDL) model of chronic hepatic encephalopathy (HE). Four weeks after BDL surgery, a significant increase was… read more here.
Keywords: bdl rats; permeability; expression; junction proteins ... See more keywords
Esrp1-Regulated Splicing of Arhgef11 Isoforms Is Required for Epithelial Tight Junction Integrity
Sign Up to like & getrecommendations! Published in 2018 at "Cell reports"
DOI: 10.1016/j.celrep.2018.10.097
Abstract: SUMMARY The epithelial-specific splicing regulators Esrp1 and Esrp2 are required for mammalian development, including establishment of epidermal barrier functions. However, the mechanisms by which Esrp ablation causes defects in epithelial barriers remain undefined. We determined… read more here.
Keywords: arhgef11; epithelial tight; tight junction; junction integrity ... See more keywords
Whole transcriptome-based ceRNA network analysis revealed ochratoxin A-induced compromised intestinal tight junction proteins through WNT/Ca2+ signaling pathway.
Sign Up to like & getrecommendations! Published in 2021 at "Ecotoxicology and environmental safety"
DOI: 10.1016/j.ecoenv.2021.112637
Abstract: Ochratoxin A (OTA) is a widespread environmental pollutant that is a threat to humans and livestock and remains a global concern to public health. It has negative effects on both humans and animals that are… read more here.
Keywords: whole transcriptome; intestinal barrier; analysis; wnt ca2 ... See more keywords
An agonist of a zinc‐sensing receptor GPR39 enhances tight junction assembly in intestinal epithelial cells via an AMPK‐dependent mechanism
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DOI: 10.1016/j.ejphar.2018.10.038
Abstract: Abstract Intestinal barrier function depends on integrity of tight junctions, which serve as barriers to transepithelial influx of noxious substances/microorganisms from gut lumen. The G‐protein coupled receptor 39 (GPR39) is a zinc‐sensing receptor, which is… read more here.
Keywords: zinc; gpr39; junction assembly; receptor ... See more keywords
Shen-Fu Decoction could ameliorate intestinal permeability by regulating the intestinal expression of tight junction proteins and p-VASP in septic rats.
Sign Up to like & getrecommendations! Published in 2020 at "Journal of ethnopharmacology"
DOI: 10.1016/j.jep.2020.113562
Abstract: ETHNOPHARMACOLOGICAL RELEVANCE Shen-Fu Decoction (SFD), a classic Traditional Chinese paired herb formulation, has been widely used for the treatment of sepsis in China. This study was carried out to assess the effects of SFD in… read more here.
Keywords: sepsis; intestinal permeability; permeability regulating; tight junction ... See more keywords
The tight junction protein cingulin regulates the vascular response to burn injury in a mouse model.
Sign Up to like & getrecommendations! Published in 2020 at "Microvascular research"
DOI: 10.1016/j.mvr.2020.104067
Abstract: Edema formation due to the collapse of physiological barriers and the associated delayed healing process is still a central problem in the treatment of burn injuries. In healthy individuals, tight junctions form a barrier to… read more here.
Keywords: burn injury; edema formation; cingulin; injury ... See more keywords