Targeting the tight junction protein, zonula occludens-1, with the connexin43 mimetic peptide, αCT1, reduces VEGF-dependent RPE pathophysiology
Sign Up to like & getrecommendations! Published in 2017 at "Journal of Molecular Medicine"
DOI: 10.1007/s00109-017-1506-8
Abstract: A critical target tissue in age-related macular degeneration (AMD) is the retinal pigment epithelium (RPE), which forms the outer blood-retina barrier (BRB). RPE-barrier dysfunction might result from attenuation/disruption of intercellular tight junctions. Zonula occludens-1 (ZO-1)… read more here.
Keywords: connexin43 mimetic; zonula occludens; ct1; rpe pathophysiology ... See more keywords
Impaired vagus function in rats suppresses bile acid synthesis in the liver by disrupting tight junctions and activating Fxr-Fgf15 signaling in the intestine.
Sign Up to like & getrecommendations! Published in 2018 at "Biochemical and biophysical research communications"
DOI: 10.1016/j.bbrc.2017.11.201
Abstract: Bile acids (BAs) circulate between the liver and intestine, and regulate the homeostasis of glucose, lipid, and energy. Recent studies demonstrated an essential role of BAs in neurological diseases, suggesting an interaction between BAs and… read more here.
Keywords: intestine; function rats; impaired vagus; liver ... See more keywords
Phase Separation of Zonula Occludens Proteins Drives Formation of Tight Junctions
Sign Up to like & getrecommendations! Published in 2019 at "Cell"
DOI: 10.1016/j.cell.2019.10.011
Abstract: Tight junctions are cell-adhesion complexes that seal tissues and are involved in cell polarity and signaling. Supra-molecular assembly and positioning of tight junctions as continuous networks of adhesion strands are dependent on the membrane-associated scaffolding… read more here.
Keywords: occludens proteins; phase separation; tight junctions; formation ... See more keywords
Endothelial tight junctions and their regulatory signaling pathways in vascular homeostasis and disease.
Sign Up to like & getrecommendations! Published in 2019 at "Cellular signalling"
DOI: 10.1016/j.cellsig.2019.109485
Abstract: Endothelial tight junctions (TJs) regulate the transport of water, ions, and molecules through the paracellular pathway, serving as an important barrier in blood vessels and maintaining vascular homeostasis. In endothelial cells (ECs), TJs are highly… read more here.
Keywords: signaling pathways; endothelial tight; vascular homeostasis; tjs ... See more keywords
Imidacloprid increases intestinal permeability by disrupting tight junctions.
Sign Up to like & getrecommendations! Published in 2021 at "Ecotoxicology and environmental safety"
DOI: 10.1016/j.ecoenv.2021.112476
Abstract: The neonicotinoid pesticide, imidacloprid (IMI), is frequently detected in the environment and in foods. It is absorbed and metabolized by the intestine; however, its effects on intestinal barrier integrity are not well studied. We investigated… read more here.
Keywords: intestinal epithelial; barrier; intestinal permeability; permeability ... See more keywords
Physiological pressure enhances the formation of tight junctions in engineered and native corneal endothelium.
Sign Up to like & getrecommendations! Published in 2019 at "Experimental eye research"
DOI: 10.1016/j.exer.2018.11.004
Abstract: Cells and tissues are influenced by environmental conditions. In vivo, the corneal endothelium is subjected to hydrostatic intraocular pressure (IOP) and to the hydrokinetic pressure of the moving aqueous humor in the anterior chamber. In… read more here.
Keywords: endothelium; corneal endothelium; tight junctions; formation tight ... See more keywords
Intracellular amyloid-β disrupts tight junctions of the retinal pigment epithelium via NF-κB activation
Sign Up to like & getrecommendations! Published in 2020 at "Neurobiology of Aging"
DOI: 10.1016/j.neurobiolaging.2020.07.013
Abstract: Drusen are focal deposits between the retinal pigment epithelium (RPE) and Bruch's membrane in the retina of patients with age-related macular degeneration. Amyloid-β is one of the important components of drusen, which leads to local… read more here.
Keywords: intracellular amyloid; amyloid; pigment epithelium; tight junctions ... See more keywords
Manipulating ocular endothelial tight junctions: Applications in treatment of retinal disease pathology and ocular hypertension
Sign Up to like & getrecommendations! Published in 2018 at "Progress in Retinal and Eye Research"
DOI: 10.1016/j.preteyeres.2017.09.003
Abstract: Protein levels of endothelial tight-junctions of the inner retinal microvasculature, together with those of Schlemm's canal, can be readily manipulated by RNA interference (RNAi), resulting in the paracellular clefts between such cells to be reversibly… read more here.
Keywords: ocular endothelial; endothelial tight; junctions applications; pathology ... See more keywords
Computational Assessment of Different Structural Models for Claudin-5 Complexes in Blood–Brain Barrier Tight Junctions
Sign Up to like & getrecommendations! Published in 2022 at "ACS Chemical Neuroscience"
DOI: 10.1021/acschemneuro.2c00139
Abstract: The blood-brain barrier (BBB) strictly regulates the exchange of ions and molecules between the blood and the central nervous system. The tight junctions (TJs) are multimeric structures that control the transport through the paracellular spaces… read more here.
Keywords: tight junctions; blood brain; different structural; brain barrier ... See more keywords
Zwitterionic micelles efficiently deliver oral insulin without opening tight junctions
Sign Up to like & getrecommendations! Published in 2020 at "Nature Nanotechnology"
DOI: 10.1038/s41565-020-0693-6
Abstract: Oral delivery of protein drugs is considered a life-changing solution for patients who require regular needle injections. However, clinical translation of oral protein formulations has been hampered by inefficient penetration of drugs through the intestinal… read more here.
Keywords: protein; insulin; oral insulin; opening tight ... See more keywords
Knockdown of IQGAP-1 Enhances Tight Junctions and Prevents P. aeruginosa Invasion of Human Corneal Epithelial Cells
Sign Up to like & getrecommendations! Published in 2019 at "Ocular Immunology and Inflammation"
DOI: 10.1080/09273948.2019.1642494
Abstract: ABSTRACT Purpose To determine the role of IQ-domain GTPase-activating protein1 (IQGAP-1) in tight junctions of human corneal epithelial cells (HCECs) and its effect against P. aeruginosa (PAK) invasion. Material and Methods Primary human corneal epithelial… read more here.
Keywords: epithelial cells; invasion; corneal epithelial; iqgap ... See more keywords