A novel bispecific nanobody with PD-L1/TIGIT dual immune checkpoint blockade.
Sign Up to like & getrecommendations! Published in 2020 at "Biochemical and biophysical research communications"
DOI: 10.1016/j.bbrc.2020.07.072
Abstract: Cancer immunotherapy have changed the paradigm of cancer treatment, but there remains a great need for improvement given that less patients with tumors respond to the treatment of PD-1/PD-L1 blockade. TIGIT (also called T cell… read more here.
Keywords: immune checkpoint; tigit; blockade; cell ... See more keywords
Enhanced expression of TIGIT but not neuropilin-1 in patients with type 2 diabetes mellitus.
Sign Up to like & getrecommendations! Published in 2020 at "Immunology letters"
DOI: 10.1016/j.imlet.2020.06.003
Abstract: BACKGROUND The aggressive T helper cell responses and regulatory T (Treg) cells dysfunction exist in type 2 diabetes mellitus (T2DM). The co-inhibitory T cell immunoglobulin and ITIM-domain (TIGIT), neuropilin-1 (Nrp-1), and the co-stimulatory CD226 play… read more here.
Keywords: tigit; expression tigit; diabetes mellitus; type diabetes ... See more keywords
CD155 mutation (Ala67Thr) increases the binding affinity for and the signaling via an inhibitory immunoreceptor TIGIT
Sign Up to like & getrecommendations! Published in 2022 at "Cancer Science"
DOI: 10.1111/cas.15526
Abstract: CD155 is a shared ligand for activating and inhibitory immunoreceptors DNAX accessory molecule 1 (DNAM‐1), also called CD226, and T cell immunoglobulin and immunoreceptor tyrosine‐based inhibitory motif domain (TIGIT), which are expressed on natural killer… read more here.
Keywords: binding affinity; tigit; immunoreceptor; mutation ... See more keywords
TIGIT Blockade and IL15 in Tumor Immunotherapy: Together is Better
Sign Up to like & getrecommendations! Published in 2020 at "Clinical Cancer Research"
DOI: 10.1158/1078-0432.ccr-20-2538
Abstract: IL15 and TIGIT blockade enhances the natural killer (NK) cell–mediated activity against MHC-I–deficient melanoma both in vitro and in preclinical models. IL15-induced harnessing of NK cells, associated with their unleashing by TIGIT blockade, may represent… read more here.
Keywords: tumor immunotherapy; blockade il15; tigit; tigit blockade ... See more keywords
Abstract 3477: Maximizing the outcome of CD226 stimulation through targeting beyond TIGIT signaling with combination and multi-specific approaches for cancer immunotherapy
Sign Up to like & getrecommendations! Published in 2023 at "Cancer Research"
DOI: 10.1158/1538-7445.am2023-3477
Abstract: The CD226 (DNAM-1) axis has emerged as an important immune-modulatory pathway that regulates T cell and NK cell effector functions in the solid tumor microenvironment. Three inhibitory receptors, TIGIT, CD96, and PVRIG, inhibit the activating… read more here.
Keywords: multi specific; tigit; maximizing outcome; tumor ... See more keywords
A TIGIT-based chimeric co-stimulatory switch receptor improves T-cell anti-tumor function
Sign Up to like & getrecommendations! Published in 2019 at "Journal for Immunotherapy of Cancer"
DOI: 10.1186/s40425-019-0721-y
Abstract: BackgroundTumors can employ different mechanisms to evade immune surveillance and function. Overexpression of co-inhibitory ligands that bind to checkpoint molecules on the surface of T-cells can greatly impair the function of latter. TIGIT (T cell… read more here.
Keywords: tigit; tumor function; anti tumor; function ... See more keywords
The immunomodulatory molecule TIGIT is expressed by chronic lymphocytic leukemia cells and contributes to anergy.
Sign Up to like & getrecommendations! Published in 2023 at "Haematologica"
DOI: 10.3324/haematol.2022.282177
Abstract: T-cell immunoreceptor with Ig and ITIM domains (TIGIT) is an inhibitory checkpoint receptor that negatively regulates T cell responses. CD226 competes with TIGIT for binding to the CD155 ligand, delivering a positive signal to the… read more here.
Keywords: cell; lymphocytic leukemia; tigit; expression ... See more keywords
Defining the Immune Checkpoint Landscape in Human Colorectal Cancer Highlights the Relevance of the TIGIT/CD155 Axis for Optimizing Immunotherapy
Sign Up to like & getrecommendations! Published in 2022 at "Cancers"
DOI: 10.3390/cancers14174261
Abstract: Simple Summary One promising avenue for the treatment of colorectal cancer is the reinvigoration of pre-existing anti-tumor T-cell responses by overcoming inhibitions that arise from the T-cell expression of immune checkpoints. This study aims to… read more here.
Keywords: immune checkpoint; tigit; colorectal cancer; tumor ... See more keywords
Expression of the immune checkpoint receptor TIGIT in seminoma
Sign Up to like & getrecommendations! Published in 2019 at "Oncology Letters"
DOI: 10.3892/ol.2019.10428
Abstract: A characteristic feature of testicular seminoma is the abundance of immune cells in the tumor microenvironment, raising the possibility that immune checkpoint inhibitors may serve as a therapeutic option in these types of tumors. T… read more here.
Keywords: immune checkpoint; tigit; checkpoint receptor; checkpoint ... See more keywords