Higher TIGIT+CD226- γδ T cells in Patients with Acute Myeloid Leukemia.
Sign Up to like & getrecommendations! Published in 2020 at "Immunological investigations"
DOI: 10.1080/08820139.2020.1806868
Abstract: The diverse structural and functional heterogeneity of γδ T cells is related to their distinct role in cancer immunity. The different phenotypes of γδ T cells in patients with acute myeloid leukemia (AML) is far… read more here.
Keywords: cd226 cells; myeloid leukemia; tigit cd226; acute myeloid ... See more keywords
TIGIT-Fc Prolongs Corneal Allograft Survival in Mice by Upregulating TIGIT/CD226 Expression and the Proportion of Helios+Foxp3+ Treg Cells
Sign Up to like & getrecommendations! Published in 2022 at "Transplantation"
DOI: 10.1097/tp.0000000000004257
Abstract: Background. Reduction of graft rejection remains key issue for supporting long-term graft retention after corneal transplantation. The relevance of Treg in reduction of corneal allografts rejection has been demonstrated. It has been recently reported that… read more here.
Keywords: treg cells; tigit treatment; corneal; foxp3 treg ... See more keywords
The immunomodulatory molecule TIGIT is expressed by chronic lymphocytic leukemia cells and contributes to anergy.
Sign Up to like & getrecommendations! Published in 2023 at "Haematologica"
DOI: 10.3324/haematol.2022.282177
Abstract: T-cell immunoreceptor with Ig and ITIM domains (TIGIT) is an inhibitory checkpoint receptor that negatively regulates T cell responses. CD226 competes with TIGIT for binding to the CD155 ligand, delivering a positive signal to the… read more here.
Keywords: cell; lymphocytic leukemia; tigit; expression ... See more keywords
Examination of the TIGIT-CD226-CD112-CD155 Immune Checkpoint Network during a Healthy Pregnancy
Sign Up to like & getrecommendations! Published in 2022 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms231810776
Abstract: Background: The importance of immune checkpoint molecules is well known in tumor and transplantation immunology; however, much less information is available regarding human pregnancy. Despite the significant amount of information about the TIGIT and CD226… read more here.
Keywords: immune checkpoint; checkpoint; pregnancy; tigit cd226 ... See more keywords
TIGIT/CD226 Axis Regulates Anti-Tumor Immunity
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DOI: 10.3390/ph14030200
Abstract: Tumors escape immune surveillance by inducing various immunosuppressive pathways, including the activation of inhibitory receptors on tumor-infiltrating T cells. While monoclonal antibodies (mAbs) blocking programmed cell death 1 (PD-1), programmed death-ligand 1 (PD-L1), and cytotoxic… read more here.
Keywords: immunity; cd226 axis; axis regulates; cancer ... See more keywords