Dysfunctional role of elevated TIGIT expression on T cells in oral squmaous cell carcinoma patients.
Sign Up to like & getrecommendations! Published in 2020 at "Oral diseases"
DOI: 10.1111/odi.13703
Abstract: OBJECTIVE This study was aimed to analyze the role of T-cell immunoreceptor with immunoglobulin and tyrosine-based inhibitory motif domains (TIGIT) expression on T cells in patients with oral squamous cell carcinoma (OSCC). MATERIALS AND METHODS… read more here.
Keywords: expression cells; tigit expression; cell carcinoma; oscc patients ... See more keywords
DNA methylation regulates TIGIT expression within the melanoma microenvironment, is prognostic for overall survival, and predicts progression-free survival in patients treated with anti-PD-1 immunotherapy
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DOI: 10.1186/s13148-022-01270-2
Abstract: Background TIGIT is an immune checkpoint under investigation as therapeutic target. Understanding the regulation of TIGIT on an epigenetic level might support the development of companion biomarkers. Methods We correlated TIGIT DNA methylation of single… read more here.
Keywords: expression; tigit expression; methylation; dna methylation ... See more keywords
TIGIT Expression on Intratumoral Lymphocytes Correlates with Improved Prognosis in Oral Squamous Cell Carcinoma
Sign Up to like & getrecommendations! Published in 2022 at "Biomedicines"
DOI: 10.3390/biomedicines10123236
Abstract: (1) Background: T-cell immunoglobulin and ITIM domain (TIGIT) is a potential immunotherapeutic target in a variety of malignant entities, and antibody-based treatments are currently under investigation in clinical trials. While promising results were observed in… read more here.
Keywords: cell carcinoma; squamous cell; tigit expression; expression ... See more keywords