FCRL3 expression is upregulated and closely correlates with TIGIT expression in regulatory T cells of patients with systemic lupus erythematosus
Sign Up to like & getrecommendations! Published in 2024 at "European Journal of Immunology"
DOI: 10.1002/eji.202350739
Abstract: Using data from single-cell RNA sequencing and flow cytometry, we initially examined the expression of FCRL3, finding it to be elevated and positively associated with TIGIT expression in the regulatory T cells of patients with… read more here.
Keywords: tigit expression; patients systemic; regulatory cells; expression regulatory ... See more keywords
Dysfunctional role of elevated TIGIT expression on T cells in oral squmaous cell carcinoma patients.
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DOI: 10.1111/odi.13703
Abstract: OBJECTIVE This study was aimed to analyze the role of T-cell immunoreceptor with immunoglobulin and tyrosine-based inhibitory motif domains (TIGIT) expression on T cells in patients with oral squamous cell carcinoma (OSCC). MATERIALS AND METHODS… read more here.
Keywords: expression cells; tigit expression; cell carcinoma; oscc patients ... See more keywords
Abstract 7526: Landscape of TIGIT and PD-L1 co-expression in solid tumors
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DOI: 10.1158/1538-7445.am2024-7526
Abstract: Background: Combination treatment of solid tumors with anti-PD-1/PD-L1 and anti-TIGIT agents have shown promise in recent clinical trials. However, TIGIT co-expression with other checkpoints has not been comprehensively characterized to support identification and prioritization of… read more here.
Keywords: tigit expression; cancer; solid tumors; expression ... See more keywords
DNA methylation regulates TIGIT expression within the melanoma microenvironment, is prognostic for overall survival, and predicts progression-free survival in patients treated with anti-PD-1 immunotherapy
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DOI: 10.1186/s13148-022-01270-2
Abstract: Background TIGIT is an immune checkpoint under investigation as therapeutic target. Understanding the regulation of TIGIT on an epigenetic level might support the development of companion biomarkers. Methods We correlated TIGIT DNA methylation of single… read more here.
Keywords: expression; tigit expression; methylation; dna methylation ... See more keywords
Predicting prognosis in lung adenocarcinoma by predicting TIGIT expression: a pathomics model
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DOI: 10.21037/jtd-24-978
Abstract: Background Traditional diagnostic methods have limited efficacy in predicting the prognosis of lung adenocarcinoma (LUAD), T cell immunoreceptor with immunoglobulin and immunoreceptor tyrosine-based inhibitory motif domain (TIGIT) is a new biomarker. This study aimed to… read more here.
Keywords: tigit expression; prognosis lung; pathomics model; predicting prognosis ... See more keywords
TIGIT Expression on Intratumoral Lymphocytes Correlates with Improved Prognosis in Oral Squamous Cell Carcinoma
Sign Up to like & getrecommendations! Published in 2022 at "Biomedicines"
DOI: 10.3390/biomedicines10123236
Abstract: (1) Background: T-cell immunoglobulin and ITIM domain (TIGIT) is a potential immunotherapeutic target in a variety of malignant entities, and antibody-based treatments are currently under investigation in clinical trials. While promising results were observed in… read more here.
Keywords: cell carcinoma; squamous cell; tigit expression; expression ... See more keywords