TCR Repertoire Changes during TIL Expansion: Clonal Selection or Drifting?
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DOI: 10.1158/1078-0432.ccr-20-1560
Abstract: T-cell receptor β analysis can be exploited to monitor changes in the clonotypic composition of tumor-infiltrating lymphocyte (TIL) during ex vivo expansion in IL2. Oligoclonal TILs are often outgrown by infrequent clonotypes with greater proliferative… read more here.
Keywords: changes til; expansion; til expansion; expansion clonal ... See more keywords
Abstract 4055: CD40L stimulates melanoma infiltrating B cells and enhances ex vivo TIL expansion
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DOI: 10.1158/1538-7445.am2023-4055
Abstract: Adoptive transfer of tumor infiltrating lymphocytes (TIL) is a feasible and effective therapy for melanoma and lung cancer[1,2]. Multiple factors may determine the quality of the TIL product including components of the tumor microenvironment. In… read more here.
Keywords: cd40l; expansion; melanoma infiltrating; til expansion ... See more keywords