Abstract 1383: A CRISPR-Cas9 tiling screen to identify functional domains within DNMT1 and/or DNMT3B that can be targeted for therapeutic intervention in AML
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DOI: 10.1158/1538-7445.am2018-1383
Abstract: DNA methylation is an epigenetic mechanism that regulates gene expression during many stages of development, including genomic imprinting, stem cell regulation, and X-chromosome inactivation. Moreover, aberrant DNA methylation patterns, characterized by genome-wide hypomethylation and promoter-specific… read more here.
Keywords: cas9 tiling; tiling screen; crispr cas9; dnmt1 dnmt3b ... See more keywords