TIM‐3 polymorphism is involved in the progression of esophageal squamous cell carcinoma by regulating gene expression
Sign Up to like & getrecommendations! Published in 2021 at "Environmental and Molecular Mutagenesis"
DOI: 10.1002/em.22432
Abstract: The T‐cell immunoglobulin and mucin domain containing molecule 3 (TIM‐3), a crucial immune regulatory molecule, is an emerging immune checkpoint target for cancer therapy. Our study aimed to investigate the association between TIM‐3 polymorphisms (rs10053538… read more here.
Keywords: squamous cell; escc; expression; tim ... See more keywords
TIM-3 blockade combined with bispecific antibody MT110 enhances the anti-tumor effect of γδ T cells
Sign Up to like & getrecommendations! Published in 2020 at "Cancer Immunology, Immunotherapy"
DOI: 10.1007/s00262-020-02638-0
Abstract: As ideal cells that can be used for adoptive cell therapy, γδ T cells are a group of homogeneous cells with high proliferative and tumor killing ability. However, γδ T cells are apt to apoptosis… read more here.
Keywords: antibody mt110; anti tumor; tim; bispecific antibody ... See more keywords
New Checkpoint Inhibitors on the Road: Targeting TIM-3 in Solid Tumors
Sign Up to like & getrecommendations! Published in 2022 at "Current Oncology Reports"
DOI: 10.1007/s11912-022-01218-y
Abstract: Even though checkpoint inhibitors have become a recent milestone for the treatment of many different tumor types, eventually, most part of patients will develop resistance mechanisms and their disease will progress. New generations of checkpoint… read more here.
Keywords: tim; new checkpoint; inhibitors road; road targeting ... See more keywords
Blockade of PD-1 and TIM-3 immune checkpoints fails to restore the function of exhausted CD8+ T cells in early clinical stages of chronic lymphocytic leukemia.
Sign Up to like & getrecommendations! Published in 2020 at "Immunologic research"
DOI: 10.1007/s12026-020-09146-4
Abstract: Blocking antibodies targeting immune checkpoint molecules achieved invaluable success in tumor therapy and amazing clinical responses in a variety of cancers. Although common treatment protocols have improved overall survival in patients with chronic lymphocytic leukemia… read more here.
Keywords: lymphocytic leukemia; blocking antibodies; cd8 cells; chronic lymphocytic ... See more keywords
Celebrity attraction in the minors: the case of Tim Tebow
Sign Up to like & getrecommendations! Published in 2019 at "Journal of Economics and Finance"
DOI: 10.1007/s12197-019-9470-5
Abstract: The movement of former college football star and NFL player Tim Tebow to the sport of baseball attracted considerable attention in 2017. Although many viewed his desire to play baseball as a publicity stunt, the… read more here.
Keywords: celebrity attraction; tim; minors case; tim tebow ... See more keywords
Multicenter, Randomized, Controlled Study Comparing Tafluprost/Timolol Fixed Combination with Latanoprost/Timolol Fixed Combination in Primary Open-Angle Glaucoma and Ocular Hypertension
Sign Up to like & getrecommendations! Published in 2018 at "Advances in Therapy"
DOI: 10.1007/s12325-018-0718-9
Abstract: IntroductionThis was the first exploratory randomized controlled study to compare the efficacy and safety of a preserved tafluprost/timolol fixed combination (TAF/TIM) with a preserved latanoprost/timolol fixed combination (LAT/TIM).MethodsThis prospective, randomized, open-label study was conducted in… read more here.
Keywords: taf tim; lat tim; timolol fixed; tim ... See more keywords
Efficiently Targeting Metastatic Osteosarcoma, Neuroblastoma and Glioblastoma with Ex-Vivo Expanded Natural Killer Cells Combined with N-803 (ALT-803, IL-15 Superagonist) and TIM-3 Blockage
Sign Up to like & getrecommendations! Published in 2019 at "Biology of Blood and Marrow Transplantation"
DOI: 10.1016/j.bbmt.2018.12.543
Abstract: Background The overall survival rate for pediatric osteosarcoma (OS), neuroblastoma (NB) and glioblastoma (GBM) in children with relapsed/refractory and metastatic disease remains dismal. Our group has successfully expanded peripheral blood Natural Killer cells (exPBNK) with… read more here.
Keywords: osteosarcoma neuroblastoma; tim; natural killer; tim blockage ... See more keywords
Evaluating the catalytic importance of a conserved Glu97 residue in triosephosphate isomerase.
Sign Up to like & getrecommendations! Published in 2018 at "Biochemical and biophysical research communications"
DOI: 10.1016/j.bbrc.2018.09.076
Abstract: Investigating enzyme activity is central to our understanding of biological function, and the design of biocatalysts continues to find applications in synthesis. While a role for active site residues can be proposed based on structure… read more here.
Keywords: triosephosphate isomerase; active site; site; tim ... See more keywords
Expression of Tim-3 drives phenotypic and functional changes in Treg cells in secondary lymphoid organs and the tumor microenvironment
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DOI: 10.1016/j.celrep.2021.109699
Abstract: SUMMARY Regulatory T cells (Treg cells) are critical mediators of self-tolerance, but they can also limit effective anti-tumor immunity. Although under homeostasis a small fraction of Treg cells in lymphoid organs express the putative checkpoint… read more here.
Keywords: treg cells; lymphoid organs; expression; tim ... See more keywords
Thermal behavior improvement of hollow sintered bricks integrated with both thermal insulation material (TIM) and Phase-Change Material (PCM)
Sign Up to like & getrecommendations! Published in 2021 at "Case Studies in Thermal Engineering"
DOI: 10.1016/j.csite.2021.100938
Abstract: Abstract Thermal Insulation Material (TIM) or Phase-Change Material (PCM) had been often employed to improve the thermal performance of hollow sintered bricks. To gain the reasonable and effective filling groups of TIM or PCM, seven… read more here.
Keywords: pcm; tim; thermal insulation; material ... See more keywords
A Co-Inhibitory Alliance in Myeloid Leukemia: TIM-3/Galectin-9 Complex as a New Target for Checkpoint Blockade Therapy
Sign Up to like & getrecommendations! Published in 2017 at "EBioMedicine"
DOI: 10.1016/j.ebiom.2017.08.002
Abstract: Article history: Received 3 August 2017 Accepted 3 August 2017 Available online 4 August 2017 tion (Ozkazanc et al., 2016). Of note, under the control of these multiple inhibitory receptors, the effector T cells easily… read more here.
Keywords: inhibitory alliance; myeloid leukemia; alliance myeloid; august 2017 ... See more keywords