Tim-4 expression increases in ischemic stroke patients and is associated with poor outcome
Sign Up to like & getrecommendations! Published in 2018 at "Journal of Neuroimmunology"
DOI: 10.1016/j.jneuroim.2017.11.017
Abstract: T cell immunoglobin and mucin domain (Tim)-4 on monocytes is involved in immune regulation. Here, we investigated Tim-4 expression on circulating monocytes and in plasma of ischemic stroke. Tim-4 expression was significantly increased on day… read more here.
Keywords: monocytes plasma; ischemic stroke; expression; tim expression ... See more keywords
On the significance of Tim-3 expression in pancreatic cancer
Sign Up to like & getrecommendations! Published in 2017 at "Saudi Journal of Biological Sciences"
DOI: 10.1016/j.sjbs.2017.11.006
Abstract: Objective We aim to explore the connection between Tim-3 expression in both cancerous pancreatic and pericarcinous tissues and the clinicopathological features of pancreatic cancer. We will also preliminarily assess the role and significance of Tim-3… read more here.
Keywords: tim expression; expression pancreatic; pancreatic cancer;
T‐bet‐mediated Tim‐3 expression dampens monocyte function during chronic hepatitis C virus infection
Sign Up to like & getrecommendations! Published in 2017 at "Immunology"
DOI: 10.1111/imm.12686
Abstract: Hepatitis C virus (HCV) induces a high rate of chronic infection via dysregulation of host immunity. We have previously shown that T‐cell immunoglobulin and mucin domain protein‐3 (Tim‐3) is up‐regulated on monocyte/macrophages (M/Mφ) during chronic… read more here.
Keywords: tim expression; expression; hepatitis virus; hcv infection ... See more keywords
Tim-3 Expression Causes NK Cell Dysfunction in Type 2 Diabetes Patients
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Immunology"
DOI: 10.3389/fimmu.2022.852436
Abstract: Type 2 diabetes mellitus (T2DM) is characterized by high blood glucose levels and chronic low-grade inflammation. It shows a strong association with obesity and immune dysfunction, which makes T2DM patients more susceptible to infectious diseases.… read more here.
Keywords: expression; type diabetes; cell dysfunction; tim expression ... See more keywords
TIM-3 Expression Is Downregulated on Human NK Cells in Response to Cancer Targets in Synergy with Activation
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DOI: 10.3390/cancers12092417
Abstract: Among natural killer (NK) cell receptors, the T-cell immunoglobulin and mucin-containing domain (TIM-3) has been associated with both inhibitory and activating functions, depending on context and activation pathway. Ex vivo and in vitro, expression of… read more here.
Keywords: expression downregulated; expression; cancer targets; activation ... See more keywords
In Acute Dengue Infection, High TIM-3 Expression May Contribute to the Impairment of IFNγ Production by Circulating Vδ2 T Cells
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DOI: 10.3390/v14010130
Abstract: γδ T cells are innate cells able to quickly eliminate pathogens or infected/tumoral cells by their antiviral and adjuvancy activities. The role of γδ T cells during Dengue Viral Infection (DENV) infection is not fully… read more here.
Keywords: dengue infection; infection; acute dengue; tim expression ... See more keywords
Tim-3 expression in glioma cells is associated with drug resistance
Sign Up to like & getrecommendations! Published in 2019 at "Journal of Cancer Research and Therapeutics"
DOI: 10.4103/jcrt.jcrt_630_18
Abstract: Objective: T-cell immunoglobulin and mucin-domain containing-3 (Tim-3) has been widely recognized as a negative regulator of antitumor immunity. However, the mechanism by which Tim-3 suppresses antitumor treatment in gliomas remains unclear. This study aims to… read more here.
Keywords: tim expression; glioma; drug; tim ... See more keywords