Tim-3, Lag-3, and TIGIT.
Sign Up to like & getrecommendations! Published in 2017 at "Current topics in microbiology and immunology"
DOI: 10.1007/82_2017_62
Abstract: Co-inhibitory receptors play a key role in regulating T cell responses and maintaining immune homeostasis. Their inhibitory function prevents autoimmune responses but also restricts the ability of T cells to mount effective immune responses against… read more here.
Keywords: inhibitory receptors; lag tigit; tim lag;
Genetic signature of CTLA-4, BTLA, TIM-3 and LAG-3 molecular expression in colorectal cancer patients: implications in diagnosis and survival outcomes.
Sign Up to like & getrecommendations! Published in 2021 at "Clinical biochemistry"
DOI: 10.1016/j.clinbiochem.2021.06.007
Abstract: OBJECTIVE Accumulating evidences suggest that immune checkpoints (ICs) inhibit immune response against cancerous cells and promote tumor cell survival. Up-regulation of ICs in tumor microenvironment is reported in patients with colorectal cancer (CRC). Thus, evaluating… read more here.
Keywords: btla; expression; ctla btla; tim lag ... See more keywords
The Role of TIM-3 and LAG-3 in the Microenvironment and Immunotherapy of Ovarian Cancer
Sign Up to like & getrecommendations! Published in 2022 at "Biomedicines"
DOI: 10.3390/biomedicines10112826
Abstract: Ovarian cancer has the highest mortality rate among gynecologic malignancies. The main treatment options are surgical removal of the tumor and chemotherapy. Cancer treatment has been revolutionized by immunotherapy, which has developed explosively over the… read more here.
Keywords: lag; immunotherapy; ovarian cancer; expression ... See more keywords