TIM-3 signaling hijacks the canonical Wnt/β-catenin pathway to maintain cancer stemness in acute myeloid leukemia
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DOI: 10.1182/bloodadvances.2022008405
Abstract: Key Points • TIM-3/Gal-9 autocrine loop hijacks and constitutively activates canonical Wnt pathway in AML LSCs.• To hijack canonical Wnt pathway, HCK and p120-catenin, highly expressed on AML LSCs, play crucial roles in signal transduction… read more here.
Keywords: canonical wnt; catenin; wnt; signaling hijacks ... See more keywords