Defining the architecture of the human TIM22 complex by chemical crosslinking
Sign Up to like & getrecommendations! Published in 2020 at "FEBS Letters"
DOI: 10.1002/1873-3468.13978
Abstract: The majority of mitochondrial proteins are nuclear encoded and imported into mitochondria as precursor proteins via dedicated translocases. The translocase of the inner membrane 22 (TIM22) is a multisubunit molecular machine specialized for the translocation… read more here.
Keywords: tim22 complex; architecture human; tim22; human tim22 ... See more keywords
Defining the Substrate Spectrum of the TIM22 Complex Identifies Pyruvate Carrier Subunits as Unconventional Cargos
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DOI: 10.1016/j.cub.2020.01.024
Abstract: Summary In mitochondria, the carrier translocase (TIM22 complex) facilitates membrane insertion of multi-spanning proteins with internal targeting signals into the inner membrane [1, 2, 3]. Tom70, a subunit of TOM complex, represents the major receptor… read more here.
Keywords: tim22 complex; substrate spectrum; tim22; carrier ... See more keywords
Functional crosstalk between the TIM22 complex and YME1 machinery maintains mitochondrial proteostasis and integrity.
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DOI: 10.1242/jcs.260060
Abstract: The TIM22 pathway cargos are essential for sustaining mitochondrial homeostasis as an excess of these proteins leads to proteostatic stress and cell death. Yme1 is an inner membrane metalloprotease that regulates protein quality control with… read more here.
Keywords: tim22 complex; tim22; yme1; complex yme1 ... See more keywords