Stendomycin selectively inhibits TIM23-dependent mitochondrial protein import.
Sign Up to like & getrecommendations! Published in 2017 at "Nature chemical biology"
DOI: 10.1038/nchembio.2493
Abstract: Tim17 and Tim23 are the main subunits of the TIM23 complex, one of the two major essential mitochondrial inner-membrane protein translocon machineries (TIMs). No chemical probes that specifically inhibit TIM23-dependent protein import were known to… read more here.
Keywords: protein; protein import; tim23 dependent; tim23 complex ... See more keywords
Hotspots for Disease-Causing Mutations in the Mitochondrial TIM23 Import Complex
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DOI: 10.3390/genes15121534
Abstract: The human mitochondrial proteome comprises approximately 1500 proteins, with only 13 being encoded by mitochondrial DNA. The remainder are encoded by the nuclear genome, translated by cytosolic ribosomes, and subsequently imported into and sorted within… read more here.
Keywords: tim23 complex; hotspots disease; disease causing; import ... See more keywords