T‐cell immunoglobulin mucin 3 blockade drives an antitumor immune response in head and neck cancer
Sign Up to like & getrecommendations! Published in 2017 at "Molecular Oncology"
DOI: 10.1002/1878-0261.12029
Abstract: T‐cell immunoglobulin mucin 3 (TIM3) contributes to immune suppression during progression of many cancers, but the precise role of TIM3 in head and neck squamous cell carcinoma (HNSCC) is not clearly understood. In this study,… read more here.
Keywords: immunoglobulin mucin; tim3; expression; cell immunoglobulin ... See more keywords
Construction and Preclinical Evaluation of 124I/125I-Labeled Antibody Targeting T Cell Immunoglobulin and Mucin Domain-3.
Sign Up to like & getrecommendations! Published in 2024 at "Molecular pharmaceutics"
DOI: 10.1021/acs.molpharmaceut.3c01046
Abstract: T cell immunoglobulin and mucin domain-3 (TIM3; HAVCR2) is a transmembrane protein that exerts negative regulatory control over T cell responses. Studies have demonstrated an upregulation of TIM3 expression in tumor-infiltrating lymphocytes (TILs) in cancer… read more here.
Keywords: c23; 124i 125i; cell; 125i c23 ... See more keywords
Opposing regulatory functions of the TIM3 (HAVCR2) signalosome in primary effector T cells as revealed by quantitative interactomics
Sign Up to like & getrecommendations! Published in 2020 at "Cellular and Molecular Immunology"
DOI: 10.1038/s41423-020-00575-7
Abstract: Deciphering how T-cell antigen receptor signals are modulated by coinhibitors is a fundamental goal in immunology and of considerable clinical interest because blocking coinhibitory signals via therapeutic antibodies have become a standard cancer immunotherapeutic strategy.… read more here.
Keywords: stimulation; tim3; effector cells; fig ... See more keywords
TIM3-blockade synergizes with IL2 in alleviating intra-tumoral CD8+T cell exhaustion
Sign Up to like & getrecommendations! Published in 2025 at "Nature Communications"
DOI: 10.1038/s41467-025-60463-4
Abstract: TIM3, a T-cell inhibitory receptor, is expressed on exhausted T cells in the TME. Progressive loss of IL2-secretion is an early sign of diminished effector function in TILs, which raises the possibility of IL2 loss… read more here.
Keywords: anti tim3; exhaustion; tim3 proil2v2; cell ... See more keywords
Adenosine 2A receptor and TIM3 suppress cytolytic killing of tumor cells via cytoskeletal polarization
Sign Up to like & getrecommendations! Published in 2022 at "Communications Biology"
DOI: 10.1038/s42003-021-02972-8
Abstract: Tumors generate an immune-suppressive environment that prevents effective killing of tumor cells by CD8 + cytotoxic T cells (CTL). It remains largely unclear upon which cell type and at which stage of the anti-tumor response… read more here.
Keywords: tumor; tumor cells; cytoskeletal polarization; adenosine receptor ... See more keywords
IMMU-27. IMMUNE CHECKPOINT BLOCKADE OF EX VIVO EXPANDED T CELLS FOR USE IN ADOPTIVE CELLULAR THERAPY (ACT) FOR GLIOBLASTOMA
Sign Up to like & getrecommendations! Published in 2019 at "Neuro-Oncology"
DOI: 10.1093/neuonc/noz175.520
Abstract: Despite aggressive treatments, GBM continues to have unacceptably high mortality rates. Immune-checkpoint blockade and ACT have shown excellent results in other solid tumors, especially in melanoma. Unfortunately, these results have not been extrapolated to GBM.… read more here.
Keywords: checkpoint blockade; immune checkpoint; act; blockade ... See more keywords
POS0369 ELEVATED EXPRESSION OF TIM-3 ON NEUTROPHILS CORRELATES WITH DISEASE ACTIVITY AND SEVERITY OF ANKYLOSING SPONDYLITIS
Sign Up to like & getrecommendations! Published in 2021 at "Annals of the Rheumatic Diseases"
DOI: 10.1136/annrheumdis-2021-eular.3516
Abstract: Ankylosing spondylitis (AS) is a type of common, chronic inflammatory disease that compromises the axial skeleton and sacroiliac joints, causing inflammatory low back pain and progressive spinal stiffness, over time some patients develop spinal immobility… read more here.
Keywords: expression; disease activity; expressing neutrophils; tim ... See more keywords
Abstract A203: Generation of human TIM3 knock-in mice for preclinical efficacy assessment of therapeutic antibodies
Sign Up to like & getrecommendations! Published in 2018 at "Molecular Cancer Therapeutics"
DOI: 10.1158/1535-7163.targ-17-a203
Abstract: Immune checkpoint inhibitors, i.e., PD1 and CTLA4 antibody therapeutics, have led to long-term survival in many late-stage solid tumor patients. Despite this revolutionary clinical impact, the overall response rate is still low. One major roadblock… read more here.
Keywords: knock; knock mice; tim3 knock; tim3 ... See more keywords
Abstract 5629: Preclinical characterization of Sym023 a human anti-TIM3 antibody with a novel mechanism of action
Sign Up to like & getrecommendations! Published in 2018 at "Cancer Research"
DOI: 10.1158/1538-7445.am2018-5629
Abstract: Immunotherapy has become a major focus of research in oncology and blockade of immune checkpoints such as cytotoxic T-Lymphocyte Associated Protein 4 (CTLA4) and programmed cell death protein 1 (PD1) has been some of the… read more here.
Keywords: sym023 human; tim3 antibody; anti tim3; tim3 ... See more keywords
TIM3-Galectin9 axis drives CSF-1R–independent senescent macrophage and TSCM crosstalk in chronic graft-versus-host disease
Sign Up to like & getrecommendations! Published in 2025 at "Blood"
DOI: 10.1182/blood-2025-4085
Abstract: Chronic graft-versus-host disease (cGVHD) remains a major cause of morbidity post-allogeneic hematopoietic cell transplantation. Despite CSF-1R blockade depleting pro-fibrogenic macrophages, ~30% of cGVHD patients remain refractory, highlighting an urgent need to identify resistance mechanisms and… read more here.
Keywords: cgvhd; tscm; macrophage; csf ... See more keywords
NFIL3/Tim3 axis regulates effector Th1 inflammation in COPD mice
Sign Up to like & getrecommendations! Published in 2024 at "Frontiers in Immunology"
DOI: 10.3389/fimmu.2024.1482213
Abstract: Background IFN-γ+CD4+ cells (type 1 helper T cells, Th1) represent a critical component of the inflammatory environment in the lungs of chronic obstructive pulmonary disease (COPD). Identifying influencing factors related to COPD-associated Th1 cells will… read more here.
Keywords: tim3; mice; copd mice; cd4 cells ... See more keywords