Articles with "tim3 cd8" as a keyword



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PD-1+ Tim3+ tumor-infiltrating CD8 T cells sustain the potential for IFN-γ production, but lose cytotoxic activity in ovarian cancer.

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Published in 2020 at "International immunology"

DOI: 10.1093/intimm/dxaa010

Abstract: Persistent exposure to tumor antigens results in exhausted tumor-infiltrating T cells (TILs) that express the immune checkpoint molecules, PD-1 and Tim3, and lack anti-tumor immunity. To examine the exhausted status of TILs in ovarian cancer,… read more here.

Keywords: cd8 tils; ovarian cancer; cd8; tim3 cd8 ... See more keywords