Abstract A203: Generation of human TIM3 knock-in mice for preclinical efficacy assessment of therapeutic antibodies
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DOI: 10.1158/1535-7163.targ-17-a203
Abstract: Immune checkpoint inhibitors, i.e., PD1 and CTLA4 antibody therapeutics, have led to long-term survival in many late-stage solid tumor patients. Despite this revolutionary clinical impact, the overall response rate is still low. One major roadblock… read more here.
Keywords: knock; knock mice; tim3 knock; tim3 ... See more keywords