TIM3-blockade synergizes with IL2 in alleviating intra-tumoral CD8+T cell exhaustion
Sign Up to like & getrecommendations! Published in 2025 at "Nature Communications"
DOI: 10.1038/s41467-025-60463-4
Abstract: TIM3, a T-cell inhibitory receptor, is expressed on exhausted T cells in the TME. Progressive loss of IL2-secretion is an early sign of diminished effector function in TILs, which raises the possibility of IL2 loss… read more here.
Keywords: anti tim3; exhaustion; tim3 proil2v2; cell ... See more keywords