Metformin and pancreatic cancer survival: Real effect or immortal time bias?
Sign Up to like & getrecommendations! Published in 2019 at "International Journal of Cancer"
DOI: 10.1002/ijc.32254
Abstract: High heterogeneity has been reported among cohort studies investigating the association between metformin and pancreatic cancer survival. Immortal time bias may be one importance source of heterogeneity, as it is widely present in previous cohort… read more here.
Keywords: cancer survival; time bias; pancreatic cancer; immortal time ... See more keywords
Immeasurable time bias due to hospitalization in medico‐administrative databases: which impact for pharmacoepidemiological studies?
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DOI: 10.1002/pds.4193
Abstract: Drugs administered to hospitalized patients are not available within almost all health insurance databases. However, this unobservable exposure time bias is very rarely taken into account in pharmacoepidemiology. The objective was to model unobservable periods… read more here.
Keywords: time bias; bias due; due hospitalization; immeasurable time ... See more keywords
An empirical assessment of immeasurable time bias in the setting of nested case‐control studies: Statins and all‐cause mortality among patients with heart failure
Sign Up to like & getrecommendations! Published in 2019 at "Pharmacoepidemiology and Drug Safety"
DOI: 10.1002/pds.4888
Abstract: Immeasurable time bias exaggerates drug benefits in pharmacoepidemiologic studies due to exposure misclassification that occurs due to the lack of inpatient drug data in many healthcare databases. read more here.
Keywords: assessment immeasurable; bias setting; empirical assessment; time bias ... See more keywords
New methodological approaches were able to effectively reduce immeasurable time bias in case-only designs.
Sign Up to like & getrecommendations! Published in 2020 at "Journal of clinical epidemiology"
DOI: 10.1016/j.jclinepi.2020.11.004
Abstract: OBJECTIVE To assess approaches to reduce immeasurable time bias in case-crossover (CCO), case-time-control (CTC), and case-case-time-control (CCTC) designs. STUDY DESIGN AND SETTING We used Korea's healthcare database that has inpatient and outpatient prescriptions and an… read more here.
Keywords: time; case; time bias; reduce immeasurable ... See more keywords
The effect of duration of therapy for treatment of Staphylococcus aureus blood stream infection: an application of cloning to deal with immortal-time bias in an analysis of data from a cohort study (BSI-FOO)
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DOI: 10.1093/jac/dkac374
Abstract: Abstract Objective To estimate the effect of treatment duration on in-hospital mortality in patients with Staphylococcus aureus blood stream infection and demonstrate the biases that can arise when immortal-time bias is ignored. Exposure We compared… read more here.
Keywords: immortal time; time bias; therapy; treatment ... See more keywords
Emulating Target Trials to Avoid Immortal Time Bias – An Application to Antibiotic Initiation and Preterm Delivery
Sign Up to like & getrecommendations! Published in 2023 at "Epidemiology"
DOI: 10.1097/ede.0000000000001601
Abstract: Background: Randomized trials in pregnancy are extremely challenging, and observational studies are often the only option to evaluate medication safety during pregnancy. However, such studies are often susceptible to immortal time bias if treatment initiation… read more here.
Keywords: target trials; time; immortal time; time bias ... See more keywords
Letter by Cheen Regarding Article, "Outcomes Associated With Apixaban Use in Patients With End-Stage Kidney Disease and Atrial Fibrillation in the United States".
Sign Up to like & getrecommendations! Published in 2019 at "Circulation"
DOI: 10.1161/circulationaha.118.038646
Abstract: March 19, 2019 1561 McVin Hua Heng Cheen, BSc (Pharm) (Hons), PhD To the Editor: I read with great interest the article by Siontis et al1 published in Circulation. As mentioned in the commentary, current… read more here.
Keywords: time; time bias; immortal time; apixaban ... See more keywords
Immortal time bias in the association between toxicity and response for immune checkpoint inhibitors: A systematic review and meta-analysis.
Sign Up to like & getrecommendations! Published in 2020 at "Journal of Clinical Oncology"
DOI: 10.1200/jco.2020.38.15_suppl.e15080
Abstract: e15080Background: A number of studies have addressed the association between Immune related Adverse Events (IrAE) and outcome in patients treated with Immune Checkpoint Inhibitors (ICI). Only a min... read more here.
Keywords: immune checkpoint; checkpoint inhibitors; association; time bias ... See more keywords
A New Source of Heterogeneity in Comparative and Translational Clinical Trials: The “Border-Time” Bias
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DOI: 10.3390/cancers14215265
Abstract: Simple Summary Target-oriented drugs are profoundly changing the anti-cancer treatments. Progression-free survival is a primary or co-primary endpoint in the large part of comparative and translational clinical trials about target-oriented anti-cancer agents. In this context,… read more here.
Keywords: time; time bias; clinical trials; anti cancer ... See more keywords