Brexpiprazole pharmacokinetics in CYP2D6 poor metabolizers: Using physiologically-based pharmacokinetic modeling to optimize time-to-effective concentrations (JCP-21-Apr-211-R2).
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DOI: 10.1002/jcph.1946
Abstract: Brexpiprazole is an oral antipsychotic agent indicated for use in patients with schizophrenia, or as adjunctive treatment for major depressive disorder (MDD). As CYP2D6 contributes significantly to brexpiprazole metabolism, there is a label-recommended 50% reduction… read more here.
Keywords: based pharmacokinetic; physiologically based; time effective; effective concentrations ... See more keywords
Time for effective cycloplegia in patients with brown iris
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DOI: 10.1080/09273972.2021.2022716
Abstract: ABSTRACT We aimed to evaluate the time needed for effective cycloplegia after instillation of cyclopentolate 1% in patients with brown irides. A prospective analytical study involving 161 patients (322 eyes) with a mean (SD) age… read more here.
Keywords: time; effective cycloplegia; cycloplegia; time effective ... See more keywords
Time-Effective Dust Deposition Analysis of PV Modules Based on Finite Element Simulation for Candidate Site Determination
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DOI: 10.1109/access.2020.2985158
Abstract: For a photovoltaic (PV) power generation system, the shading effect of PV panels caused by dust deposition is extremely unfavorable. The deposition of dust results in a severe reduction of power generation output, since the… read more here.
Keywords: dust deposition; time effective; dust; power generation ... See more keywords