Articles with "time kill" as a keyword



Time–Kill Analysis of Ceftolozane/Tazobactam Efficacy Against Mucoid Pseudomonas aeruginosa Strains from Cystic Fibrosis Patients

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Published in 2017 at "Infectious Diseases and Therapy"

DOI: 10.1007/s40121-017-0176-8

Abstract: IntroductionMucoid Pseudomonas aeruginosa (MP) strains in cystic fibrosis (CF) patients are thought to initiate the chronic infection stage of CF and are associated with pulmonary function decline.ObjectivesThe purpose of this study was to assess the… read more here.

Keywords: tazobactam; kill analysis; ceftolozane tazobactam; time kill ... See more keywords

Effects of β-caryophyllene and Murraya paniculata essential oil in the murine hepatoma cells and in the bacteria and fungi 24-h time–kill curve studies

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Published in 2017 at "Pharmaceutical Biology"

DOI: 10.1080/13880209.2016.1254251

Abstract: Abstract Context: Orange Jessamine [Murraya paniculata L. (Rutaceae)] has been used worldwide in folk medicine as an anti-inflammatory, antibiotic and analgesic. Objective: The objective of this study is to investigate the in vitro antioxidant, cytotoxic,… read more here.

Keywords: essential oil; kill curve; time kill; activity ... See more keywords

Evaluation of dalbavancin alone and in combination with &bgr;-lactam antibiotics against resistant phenotypes of Staphylococcus aureus

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Published in 2019 at "Journal of Antimicrobial Chemotherapy"

DOI: 10.1093/jac/dky376

Abstract: Background Emergence of reduced susceptibility to vancomycin warrants the development of new antimicrobial agents for the treatment of MRSA. We evaluated the activity of dalbavancin, a novel lipoglycopeptide antibiotic, both alone and combined with β-lactams,… read more here.

Keywords: combination; phenotypes staphylococcus; resistant phenotypes; dalbavancin ... See more keywords

Phenotype‐Specific Semi‐Mechanistic Modelling of Florfenicol Time‐Kill Curves in G. Parasuis Compared to Other Respiratory Pathogens

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Published in 2025 at "Journal of Veterinary Pharmacology and Therapeutics"

DOI: 10.1111/jvp.13500

Abstract: This study examines the pharmacodynamics (PD) of florfenicol (FFN) for treating porcine respiratory diseases by comparing its effects on Glaesserella parasuis, Actinobacillus pleuropneumoniae and Pasteurella multocida. In vitro time‐kill assays and semi‐mechanistic PD modeling were… read more here.

Keywords: time kill; semi mechanistic; average free; respiratory ... See more keywords

In Vitro Time-Kill Studies of Trimethoprim/Sulfamethoxazole against Stenotrophomonas maltophilia versus Escherichia coli Using Cation-Adjusted Mueller-Hinton Broth and ISO-Sensitest Broth

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Published in 2022 at "Antimicrobial Agents and Chemotherapy"

DOI: 10.1128/aac.02167-21

Abstract: Trimethoprim/sulfamethoxazole (TMP/SMZ) is considered the treatment of choice for infections caused by Stenotrophomonas maltophilia, but limited pharmacodynamic data are available to support current susceptibility breakpoints or guide optimal dosing. Time-kill studies using a TMP/SMZ concentration… read more here.

Keywords: time; tmp smz; stenotrophomonas maltophilia; time kill ... See more keywords

ATP Bioluminescence Assay To Evaluate Antibiotic Combinations against Extensively Drug-Resistant (XDR) Pseudomonas aeruginosa

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Published in 2022 at "Microbiology Spectrum"

DOI: 10.1128/spectrum.00651-22

Abstract: Combining antibiotics is one of the few strategies available to overcome infections caused by multidrug-resistant bacteria. Time-kill curves are usually performed to evaluate antibiotic combinations, but obtaining results is too laborious to be routinely performed… read more here.

Keywords: kill curves; antibiotic combinations; method; time kill ... See more keywords

Time-Kill Curve Analysis of Fucoidan Combination with Conventional Antibiotics against Biofilms Formation of Methicillin-Resistant Staphylococcus aureus and Acinetobacter baumannii Clinical Isolates

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Published in 2024 at "Chemotherapy"

DOI: 10.1159/000542826

Abstract: Abstract Introduction: This study investigates the efficacy of fucoidan combination with antibiotics, against single-species biofilms and mixed-species, individual planktonic, and coculture planktonic conditions of Methicillin-resistant Staphylococcus aureus (MRSA) and Acinetobacter baumannii by time-kill curve analysis.… read more here.

Keywords: fucoidan combination; baumannii; time kill; species biofilms ... See more keywords

Time-Kill Kinetics of Lipid Fractions Isolated from Condiments against Foodborne Pathogens.

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Published in 2018 at "Food Technology and Biotechnology"

DOI: 10.17113/ftb.56.02.18

Abstract: Lipid fractions that are extracted from condiments have a wide array of biological potential and are commonly utilized for medicinal and culinary applications. This investigation aims at determining the antimicrobial potential of lipid fractions isolated… read more here.

Keywords: incubation; lipid fractions; fractions isolated; foodborne pathogens ... See more keywords

In vitro Evaluation of the Colistin-Carbapenem Combination in Clinical Isolates of A. baumannii Using the Checkerboard, Etest, and Time-Kill Curve Techniques

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Published in 2017 at "Frontiers in Cellular and Infection Microbiology"

DOI: 10.3389/fcimb.2017.00209

Abstract: The worldwide increase in the emergence of carbapenem resistant Acinetobacter baumannii (CRAB) calls for the investigation into alternative approaches for treatment. This study aims to evaluate colistin-carbapenem combinations against Acinetobacter spp., in order to potentially… read more here.

Keywords: combination; colistin; colistin carbapenem; time kill ... See more keywords

Appraisal of selected ethnomedicinal plants as alternative therapies against onychomycosis: Evaluation of synergy and time-kill kinetics

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Published in 2022 at "Frontiers in Pharmacology"

DOI: 10.3389/fphar.2022.1067697

Abstract: Introduction: This study aims at the biological profiling of Allium sativum, Zingiber officinale, Nigella sativa, Curcuma longa, Mentha piperita, Withania somnifera, Azadirachta indica, and Lawsonia inermis as alternatives against onychomycosis to combat the treatment challenges.… read more here.

Keywords: time; kill kinetics; non dermatophytes; mge ... See more keywords

In silico genome-scale metabolic modeling and in vitro static time-kill studies of exogenous metabolites alone and with polymyxin B against Klebsiella pneumoniae

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Published in 2022 at "Frontiers in Pharmacology"

DOI: 10.3389/fphar.2022.880352

Abstract: Multidrug-resistant (MDR) Klebsiella pneumoniae is a top-prioritized Gram-negative pathogen with a high incidence in hospital-acquired infections. Polymyxins have resurged as a last-line therapy to combat Gram-negative “superbugs”, including MDR K. pneumoniae. However, the emergence of… read more here.

Keywords: pneumoniae; klebsiella pneumoniae; static time; time kill ... See more keywords